HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 288
+	Hs
		988172 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00
+	Hs
		775066 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06
+	Hs
		775336 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		RBM22_HUMAN (2-287): 1.83e-33: 128: 15.91
+	Hs
		1102042 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP4_HUMAN (109-246): 1.66e-22: 99.2: 21.28
+	Hs
		550392 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP1_HUMAN (109-246): 3.02e-22: 98.4: 21.99
+	Hs
		1032944 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06
+	Hs
		775375 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91
+	Hs
		988089 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		TRA2B_HUMAN (1-267): 1.08e-33: 126: 100.00
+	Hs
		775060 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PABP4_HUMAN (109-246): 1.66e-22: 99.2: 21.28
+	Hs
		550147 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PABP1_HUMAN (109-246): 3.02e-22: 98.4: 21.99
+	Hs
		1127052 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		RBM39_HUMAN (15-248): 1.55e-18: 87.2: 21.83
+	Hs
		775081 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		RBM39_HUMAN (15-248): 1.55e-18: 87.2: 21.83
+	Hs
		1033312 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91
+	Hs
		686612 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		ELAV4_HUMAN (52-261): 1.01e-24: 103: 17.93
+	At
		102031 TAF15_ARATH (281-452): 1.3e-39: 149: 34.30		SUA_ARATH (80-275): 8.02e-15: 76.4: 24.50
+	Mm
		953827 Q8BQ46_MOUSE (42-460): 2.88e-40: 155: 48.34		CIRBP_MOUSE (120-192): 3.91e-11: 62.4: 57.53
+	Hs
		775076 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		HNRPD_HUMAN (106-178): 6.08e-11: 64: 26.03
+	Hs
		726754 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		TIA1_HUMAN (113-248): 7.98e-18: 84.5: 18.42
+	Mm
		915302 EWS_MOUSE (3-451): 2.27e-29: 124: 35.56		TIA1_MOUSE (113-284): 2.21e-18: 86: 15.53
+	Hs
		1032955 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		HNRPD_HUMAN (106-178): 6.08e-11: 64: 26.03