HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 1291
+	Hs
		782659 HNF4A_HUMAN (1-474): 0: 542: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		782635 HNF4A_HUMAN (1-474): 0: 542: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		782595 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Hs
		782557 HNF4A_HUMAN (1-474): 0: 542: 100.00		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		370465 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		203613 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		370223 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		203617 RARA_HUMAN (9-382): 7.34e-107: 327: 25.06		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		203673 NR1H3_HUMAN (12-373): 3.95e-102: 314: 25.89		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		203691 Q15156_HUMAN (30-382): 3.17e-98: 314: 26.50		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		370370 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		370040 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Hs
		1269380 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		369688 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		500366 RARB_HUMAN (10-424): 2.37e-114: 345: 25.23		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		1269543 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		1243831 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Mm
		93590 ERR2_MOUSE (9-375): 1.5e-99: 307: 27.37		SETD2_MOUSE (911-1290): 7.72e-54: 209: 16.71
+	Hs
		487979 RARA_HUMAN (9-382): 7.34e-107: 327: 25.06		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		1069092 Q15156_HUMAN (30-382): 3.17e-98: 314: 26.50		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13