Protein: NU116
Nucleoporin NUP116/NSP116 (Nuclear pore protein NUP116/NSP116)

Gene: NU116, NUP116
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: Q02630

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000973 - post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0003723 - RNA binding
GO:0005635 - nuclear envelope
GO:0005643 - nuclear pore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1037950

NU100
Nucleoporin NUP100/NSP100

7

20

Small-scale

0.965

High

886201

NU145
Nucleoporin NUP145

5

19

Small-scale

0.912

High

1037971

NU116
Nucleoporin NUP116/NSP116

4

19

Small-scale

0.896

High

823497

NUP82
Nucleoporin NUP82

15

8

Small-scale

0.762

High

817848

GLE2
mRNA export factor GLE2

11

20

Small-scale

0.759

High

1037990

IMB1
Importin subunit beta-1

11

20

Small-scale

0.756

High

1038013

MEX67
mRNA export factor MEX67

9

18

Small-scale

0.751

High

825171

NU159
Nucleoporin NUP159

8

19

Small-scale

0.745

High

858319

NUP85
Nucleoporin NUP85

7

9

Small-scale

0.742

High

577335

NSP1
Nucleoporin NSP1

7

19

Small-scale

0.741

High

914991

NUP84
Nucleoporin NUP84

7

16

Small-scale

0.738

High

795163

NU170
Nucleoporin NUP170

5

20

Small-scale

0.704

High

864644

NU192
Nucleoporin NUP192

5

17

Small-scale

0.703

High

782549

NU133
Nucleoporin NUP133

5

13

Small-scale

0.702

High

912747

NU188
Nucleoporin NUP188

5

8

Small-scale

0.700

High

1038006

CEX1
Cytoplasmic export protein 1

3

4

Small-scale

0.689

High

756655

NIC96
Nucleoporin NIC96

4

17

Small-scale

0.680

High

776540

NU120
Nucleoporin NUP120

4

8

Small-scale

0.680

High

916421

SEH1
Nucleoporin SEH1

4

20

Small-scale

0.680

High

734717

IMB3
Importin subunit beta-3

4

20

Small-scale

0.680

High

758047

MTR2
mRNA transport regulator MTR2

4

6

Small-scale

0.676

High

1037980

ARX1
Probable metalloprotease ARX1

3

7

Small-scale

0.658

High

877972

NUP57
Nucleoporin NUP57

3

19

Small-scale

0.658

High

886173

NUP42
Nucleoporin NUP42

3

19

Small-scale

0.641

High

1035263

NUP49
Nucleoporin NUP49/NSP49

3

19

Small-scale

0.641

High

817934

IMB4
Importin subunit beta-4

3

20

Small-scale

0.633

High

915394

MSN5
Protein MSN5

2

20

Small-scale

0.608

High

527477

HSP72
Heat shock protein SSA2

3

18

Small-scale

0.603

High

722188

XPO1
Exportin-1

2

20

High-throughput

0.600

High

1037986

SEC13
Protein transport protein SEC13

2

20

Small-scale

0.595

High

817816

NU157
Nucleoporin NUP157

2

20

Small-scale

0.585

High

1037989

NUP59
Nucleoporin ASM4

2

14

Small-scale

0.585

High

1037994

BUD20
Bud site selection protein 20

2

3

Small-scale

0.585

High

796114

IMB2
Importin subunit beta-2

2

20

Small-scale

0.584

High

858351

SAC3
Nuclear mRNA export protein SAC3

2

6

Small-scale

0.584

High

1036909

MLP1
Protein MLP1

2

20

High-throughput

0.584

High

634270

NUP1
Nucleoporin NUP1

2

19

Small-scale

0.571

High

738501

NUP2
Nucleoporin NUP2

2

20

Small-scale

0.571

High

744506

KA122
Importin beta-like protein KAP122

2

2

Small-scale

0.571

High

813428

PO152
Nucleoporin POM152

2

8

Small-scale

0.571

High

813649

NUP60
Nucleoporin NUP60

2

5

Small-scale

0.571

High

1037972

IMA1
Importin subunit alpha

2

20

Small-scale

0.571

High

1037974

KA120
Importin beta-like protein KAP120

2

20

Small-scale

0.571

High

1037979

NUP53
Nucleoporin NUP53

2

14

Small-scale

0.571

High

1038003

GLE1
mRNA export factor GLE1

2

12

Small-scale

0.571

High

745103

AFG2
ATPase family gene 2 protein

2

5

Small-scale

0.561

High

548719

RNA1
Ran GTPase-activating protein 1

1

6

Small-scale

0.561

High

721657

RENT1
ATP-dependent helicase NAM7

1

2

Small-scale

0.552

High

795503

ATG8
Autophagy-related protein 8

2

14

Small-scale

0.533

High

1038008

RTP1
RNA polymerase II assembly factor RTP1

1

1

Small-scale

0.527

High

1037976

RMT2
Protein arginine N-methyltransferase 2

2

3

Small-scale

0.526

High

1037983

RRP17
Ribosomal RNA-processing protein 17

2

1

Small-scale

0.521

High

813839

MBO1
Gamma tubulin complex adapter SPC72

2

1

High-throughput

0.513

High

524899

HSP71
Heat shock protein SSA1

1

18

Small-scale

0.501

High

1038009

RRP12
Ribosomal RNA-processing protein 12

1

2

Small-scale

0.501

High

626534

AP1
AP-1-like transcription factor YAP1

1

1

High-throughput

0.494

High

666664

AP2
AP-1-like transcription factor YAP2

1

1

High-throughput

0.494

High

1037992

PEX19
Peroxisomal membrane protein import receptor PEX19

1

1

High-throughput

0.494

High

667113

CG22
G2/mitotic-specific cyclin-2

1

6

High-throughput

0.489

High

667150

CG23
G2/mitotic-specific cyclin-3

1

6

High-throughput

0.489

High

763010

SPT7
SAGA complex subunit SPT7

1

7

High-throughput

0.489

High

893329

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

5

High-throughput

0.489

High

1037977

GCN5
Histone acetyltransferase GCN5

1

7

High-throughput

0.489

High

738908

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

8

High-throughput

0.479

High

803811

BRL1
Nucleus export protein BRL1

1

5

Small-scale

0.479

High

824773

MLP2
Protein MLP2

1

20

High-throughput

0.479

High

893287

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

13

High-throughput

0.479

High

1037975

HEH2
Inner nuclear membrane protein HEH2

1

4

Small-scale

0.479

High

1037984

SXM1
Importin beta SMX1

1

20

High-throughput

0.479

High

1038000

MDN1
Midasin

1

1

Small-scale

0.479

High

1038010

MTR10
mRNA transport regulator MTR10

1

20

High-throughput

0.479

High

1038014

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

8

High-throughput

0.479

High

817566

SERA
D-3-phosphoglycerate dehydrogenase 1

1

1

High-throughput

0.464

High

916550

TEL2
Telomere length regulation protein TEL2

1

1

High-throughput

0.464

High

919158

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.458

High

1037995

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

1031031

NOP3
Serine/arginine

1

8

Small-scale

0.457

High

445366

CDC31
Cell division control protein 31

1

4

Small-scale

0.445

High

738557

NDC1
Nucleoporin NDC1

1

5

Small-scale

0.445

High

816887

NUG1
Nuclear GTP-binding protein NUG1

1

1

Small-scale

0.445

High

923188

NOG2
Nucleolar GTP-binding protein 2

1

1

Small-scale

0.445

High

1037973

NOG1
Nucleolar GTP-binding protein 1

1

3

Small-scale

0.445

High

1037978

HAS1
ATP-dependent RNA helicase HAS1

1

1

Small-scale

0.445

High

1038005

POM34
Nucleoporin POM34

1

6

Small-scale

0.445

High

403630

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

High-throughput

0.437

High

582508

SEC23
Protein transport protein SEC23

1

5

High-throughput

0.437

High

671039

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

707954

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.437

High

727262

HS104
Heat shock protein 104

1

3

High-throughput

0.437

High

741071

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

High-throughput

0.437

High

748511

SC61A
Protein transport protein SEC61

1

3

High-throughput

0.437

High

864233

MDV1
Mitochondrial division protein 1

1

7

Small-scale

0.437

High

918521

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

8

High-throughput

0.437

High

919086

SHY1
Cytochrome oxidase assembly protein SHY1

1

1

Small-scale

0.437

High

925374

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

1037981

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

1037988

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.437

High

1038002

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.437

High

677533

KRR1
KRR1 small subunit processome component

1

0

Small-scale

0.426

High

803917

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.426

High

816541

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

Small-scale

0.426

High

918960

PESC
Pescadillo homolog

1

0

Small-scale

0.426

High

1038001

NOP53
Ribosome biogenesis protein NOP53

1

0

Small-scale

0.426

High

545968

SSB1
Ribosome-associated molecular chaperone SSB1

1

16

High-throughput

0.407

High

742218

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.407

High

819567

SSB2
Ribosome-associated molecular chaperone SSB2

1

16

High-throughput

0.407

High

825833

YRB2
Ran-specific GTPase-activating protein 2

1

20

Small-scale

0.407

High

1018319

CTR9
RNA polymerase-associated protein CTR9

1

2

Small-scale

0.407

High

1037985

RRB1
Ribosome assembly protein RRB1

1

2

Small-scale

0.407

High

1037997

BMS1
Ribosome biogenesis protein BMS1

1

2

Small-scale

0.407

High

852638

SPO74
Sporulation-specific protein 74

2

0

High-throughput

0.323

High

1037987

IVY1
Protein IVY1

2

0

High-throughput

0.323

High

756692

LTV1
Protein LTV1

1

0

High-throughput

0.282

High

797264

YBY7
UPF0303 protein YBR137W

1

0

High-throughput

0.282

High

866195

SGM1
Protein SGM1

1

0

High-throughput

0.282

High

924962

NIS1
Protein NIS1

1

0

High-throughput

0.282

High

1037999

YO289
Uncharacterized protein YOR289W

1

0

High-throughput

0.282

High

1038007

DCP1
mRNA-decapping enzyme subunit 1

1

0

High-throughput

0.282

High

1038004

RTN2
Reticulon-like protein 2

1

0

High-throughput

0.238

Low

796176

OLA1
Obg-like ATPase 1

1

0

Small-scale

0.232

Low

797782

AIM4
Altered inheritance of mitochondria protein 4

1

0

Small-scale

0.232

Low

805754

YHS7
Uncharacterized protein YHR127W

1

0

Small-scale

0.232

Low

814370

NOC2
Nucleolar complex protein 2

1

0

Small-scale

0.232

Low

817345

TPA1
Prolyl 3,4-dihydroxylase TPA1

1

0

Small-scale

0.232

Low

818265

NSA2
Ribosome biogenesis protein NSA2

1

0

Small-scale

0.232

Low

1037982

RUVB1
RuvB-like protein 1

1

0

Small-scale

0.232

Low

1037991

NOC4
Nucleolar complex protein 4

1

0

Small-scale

0.232

Low

1037993

EXP1
ER export of PMA1 protein 1

1

0

Small-scale

0.232

Low

1037996

ETT1
Enhancer of translation termination 1

1

0

Small-scale

0.232

Low

1037998

TMA46
Translation machinery-associated protein 46

1

0

Small-scale

0.232

Low

1038011

NOP14
Nucleolar complex protein 14

1

0

Small-scale

0.232

Low

1038012

PNO1
Pre-rRNA-processing protein PNO1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025