HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: FRK (P42685)
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
Gene: FRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0004715 - non-membrane spanning protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 505
+	Hs
		522833 CSK_HUMAN (1-450): 0: 543: 100.00		SRC_HUMAN (13-503): 1.23e-178: 513: 47.89
+	Hs
		412066 CSK_HUMAN (1-450): 0: 543: 100.00		FYN_HUMAN (30-503): 1.55e-177: 511: 50.63
+	Rn
		693648 CSK_RAT (1-450): 0: 543: 98.44		SRC_RAT (13-503): 3.55e-177: 510: 47.69
+	Hs
		411626 CSK_HUMAN (1-450): 0: 543: 100.00		LCK_HUMAN (33-495): 2.21e-173: 499: 48.50
+	Mm
		782841 CSK_MOUSE (1-450): 0: 543: 99.11		CSK_MOUSE (48-494): 1.66e-167: 482: 37.00
+	Hs
		782749 CSK_HUMAN (1-450): 0: 543: 100.00		CSK_HUMAN (48-494): 6.43e-167: 480: 36.78
+	Gg
		337663 SRC_CHICK (12-442): 7.32e-173: 496: 39.78		SRC_CHICK (11-503): 3.73e-179: 515: 47.70
+	Hs
		337329 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		SRC_HUMAN (13-503): 1.23e-178: 513: 47.89
+	Hs
		337307 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		FYN_HUMAN (30-503): 1.55e-177: 511: 50.63
+	Hs
		411969 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		FYN_HUMAN (30-503): 1.55e-177: 511: 50.63
+	Hs
		337315 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		HCK_HUMAN (3-496): 2.62e-175: 505: 48.61
+	Hs
		433231 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		YES_HUMAN (43-503): 6.27e-174: 502: 49.25
+	Hs
		411573 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		LCK_HUMAN (33-495): 2.21e-173: 499: 48.50
+	Dm
		337641 ABL_DROME (5-447): 1.98e-163: 502: 38.11		ABL_DROME (20-495): 1.43e-155: 484: 43.01
+	Hs
		337440 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		BTK_HUMAN (5-495): 4.67e-166: 486: 35.88
+	Mm
		337615 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		ABL1_MOUSE (33-495): 4.36e-160: 485: 42.03
+	Hs
		337293 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		ABL1_HUMAN (33-495): 1.24e-159: 484: 42.03
+	Hs
		337384 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		ABL2_HUMAN (29-502): 4.71e-157: 478: 41.05
+	Hs
		433546 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		LYN_HUMAN (21-495): 3.53e-166: 481: 49.27