HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 247
+	Hs
		782766 CSK_HUMAN (1-450): 0: 543: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		337416 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		337415 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		411661 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		789053 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		789052 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		337436 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		789060 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683181 CSK_HUMAN (1-450): 0: 543: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		782768 CSK_HUMAN (1-450): 0: 543: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		337366 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		337420 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		683185 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		337355 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		789056 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		411605 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		646706 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		337367 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		411616 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		683884 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16