Protein: 2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)

Gene: 2A5A, PPP2R5A
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q15172

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0000775 - chromosome, centromeric region
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994228

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

10

20

Small-scale

0.978

High

717817

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

8

20

Small-scale

0.974

High

718124

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

5

20

Small-scale

0.931

High

977496

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

4

20

High-throughput

0.903

High

1143882

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

2

8

High-throughput

0.789

High

1103123

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

2

8

Small-scale

0.754

High

364137

MOS
Proto-oncogene serine/threonine-protein kinase mos

5

1

High-throughput

0.717

High

942155

WNT3A
Protein Wnt-3a

4

4

High-throughput

0.691

High

1143885

SGO1
Shugoshin 1

4

4

Small-scale

0.686

High

181114

AXIN1
Axin-1

3

2

Small-scale

0.681

High

251763

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

7

Small-scale

0.679

High

1143896

DZIP1
Cilium assembly protein DZIP1

3

9

Small-scale

0.650

High

1143898

FA43A
Protein FAM43A

4

4

High-throughput

0.630

High

1143884

SGO2
Shugoshin 2

2

2

Small-scale

0.625

High

354985

CHK2
Serine/threonine-protein kinase Chk2

2

6

Small-scale

0.625

High

1143922

PPME1
Protein phosphatase methylesterase 1

1

1

High-throughput

0.618

High

1143906

CA021
Uncharacterized protein C1orf21

3

2

High-throughput

0.607

High

1095532

LIPA1
Liprin-alpha-1

2

5

High-throughput

0.606

High

1143918

AXIN2
Axin-2

2

2

High-throughput

0.606

High

624067

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

4

Small-scale

0.595

High

1131659

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

8

Small-scale

0.590

High

1086855

CDC20
Cell division cycle protein 20 homolog

2

2

Small-scale

0.584

High

852124

TNNT2
Troponin T, cardiac muscle

2

0

High-throughput

0.580

High

1143912

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.580

High

1143905

PRR14
Proline-rich protein 14

2

3

High-throughput

0.574

High

1143899

USBP1
Harmonin-binding protein USHBP1

2

1

High-throughput

0.553

High

1143904

GNL3
Guanine nucleotide-binding protein-like 3

1

0

Small-scale

0.549

High

920445

DAPK1
Death-associated protein kinase 1

1

0

Small-scale

0.537

High

324262

FA13A
Protein FAM13A

1

4

High-throughput

0.536

High

853268

CBX5
Chromobox protein homolog 5

1

2

Small-scale

0.536

High

1025619

CDK17
Cyclin-dependent kinase 17

1

3

High-throughput

0.536

High

1143900

ARHG2
Rho guanine nucleotide exchange factor 2

1

3

High-throughput

0.536

High

1143902

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.536

High

1143908

RNF41
E3 ubiquitin-protein ligase NRDP1

1

2

High-throughput

0.536

High

1143910

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.536

High

1143915

KLH14
Kelch-like protein 14

1

3

High-throughput

0.536

High

1143919

MTCL1
Microtubule cross-linking factor 1

1

4

High-throughput

0.536

High

1143920

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.536

High

596483

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

Small-scale

0.529

High

854660

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.515

High

422134

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

372079

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.513

High

683622

ITB7
Integrin beta-7

1

0

High-throughput

0.513

High

1143889

CDCA2
Cell division cycle-associated protein 2

1

1

High-throughput

0.501

High

1143893

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

322834

MTCL2
Microtubule cross-linking factor 2

1

5

High-throughput

0.489

High

1143886

NHSL1
NHS-like protein 1

1

5

High-throughput

0.489

High

1143887

MTCL3
Microtubule cross-linking factor 3

1

4

High-throughput

0.489

High

1143892

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

7

High-throughput

0.489

High

1143917

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

2

High-throughput

0.489

High

1143921

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

6

High-throughput

0.489

High

1143901

NEK1
Serine/threonine-protein kinase Nek1

1

4

Small-scale

0.481

High

353815

PTTG1
Securin

1

0

Small-scale

0.480

High

241736

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

342191

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

718570

CDC27
Cell division cycle protein 27 homolog

1

4

Small-scale

0.479

High

725256

TLX1
T-cell leukemia homeobox protein 1

1

1

Small-scale

0.479

High

904740

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

1029296

SET
Protein SET

1

1

Small-scale

0.479

High

1143888

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

Small-scale

0.479

High

1143891

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1143907

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1143911

SP110
Sp110 nuclear body protein

1

2

High-throughput

0.479

High

1143914

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

522099

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.458

High

637526

FLNA
Filamin-A

1

0

High-throughput

0.458

High

1141621

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1143883

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.458

High

1143890

FAP20
Fanconi anemia core complex-associated protein 20

1

0

Small-scale

0.458

High

1143894

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

69778

ZN785
Zinc finger protein 785

1

1

High-throughput

0.445

High

1143897

KSR1
Kinase suppressor of Ras 1

1

5

Small-scale

0.445

High

1143903

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

4

Small-scale

0.445

High

1143909

PACC1
Proton-activated chloride channel

1

1

High-throughput

0.445

High

1143913

SCN3B
Sodium channel regulatory subunit beta-3

1

6

High-throughput

0.445

High

1143923

NPTN
Neuroplastin

1

3

High-throughput

0.445

High

640173

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.438

High

1056740

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

1048356

ACVR1
Activin receptor type-1

1

0

High-throughput

0.426

High

1129547

ESPL1
Separin

1

0

Small-scale

0.426

High

1143895

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

3

High-throughput

0.407

High

1143916

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.407

High

65504

ERIC4
Glutamate-rich protein 4

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025