HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: GPR45 (Q9Y5Y3)
Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha)
Gene: GPR45

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 372
+	Hs
		787421 MTOR_HUMAN (1-2549): 0: 2102: 100.00		5HT6R_HUMAN (51-340): 1.09e-17: 85.9: 26.49
+	Hs
		723279 MTOR_HUMAN (1-2549): 0: 2102: 100.00		APJ_HUMAN (40-339): 9.8e-18: 85.5: 26.25
+	Mm
		1337542 MTOR_MOUSE (1-2549): 0: 2095: 98.94		5HT6R_MOUSE (37-340): 5.89e-17: 83.6: 24.84
+	Hs
		1031652 ATM_HUMAN (387-2548): 0: 894: 14.98		GPR45_HUMAN (1-372): 8.07e-78: 245: 100.00
+	Hs
		1038200 ATR_HUMAN (186-2548): 0: 816: 14.82		GPR45_HUMAN (1-372): 8.07e-78: 245: 100.00
+	Hs
		839272 ATM_HUMAN (387-2548): 0: 894: 14.98		5HT6R_HUMAN (51-340): 1.09e-17: 85.9: 26.49
+	Hs
		723296 ATM_HUMAN (387-2548): 0: 894: 14.98		APJ_HUMAN (40-339): 9.8e-18: 85.5: 26.25
+	Hs
		429015 PRKDC_HUMAN (695-2548): 0: 686: 14.83		ADRB2_HUMAN (2-347): 3.64e-79: 250: 22.03
+	Hs
		666304 PRKDC_HUMAN (695-2548): 0: 686: 14.83		NK3R_HUMAN (2-372): 4.55e-69: 226: 19.69
+	Hs
		839273 ATR_HUMAN (186-2548): 0: 816: 14.82		5HT6R_HUMAN (51-340): 1.09e-17: 85.9: 26.49
+	Hs
		1117821 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		GPR45_HUMAN (1-372): 8.07e-78: 245: 100.00
+	Hs
		787704 PI4KA_HUMAN (733-2453): 4.49e-160: 552: 12.12		GPR45_HUMAN (1-372): 8.07e-78: 245: 100.00
+	Hs
		723312 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		APJ_HUMAN (40-339): 9.8e-18: 85.5: 26.25
+	Hs
		723280 PI4KA_HUMAN (733-2453): 4.49e-160: 552: 12.12		APJ_HUMAN (40-339): 9.8e-18: 85.5: 26.25
+	Hs
		839285 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		5HT6R_HUMAN (51-340): 1.09e-17: 85.9: 26.49
+	Hs
		1268291 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		GPR45_HUMAN (1-372): 8.07e-78: 245: 100.00