HitPredict

Interactor 1: SCNNA (P37088)
Epithelial sodium channel subunit alpha (Alpha-ENaC) (ENaC subunit alpha) (ENaCA) (Epithelial Na(+) channel subunit alpha) (Alpha-NaCH) (Amiloride-sensitive sodium channel subunit alpha) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) (Sodium channel epithelial 1 subunit alpha)
Gene: SCNN1A

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	12876068, 15328345, 16844684, 11802777, 26651153, 11244092, 14556380, 17502380, 16416336, 18701608
Identification Methods	unspecified method, affinity chromatography technology, far western blotting, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016324 - apical plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 975
+	Hs
		902341 SCNNG_HUMAN (36-650): 0: 573: 33.44		NED4L_HUMAN (1-975): 0: 1042: 100.00
+	Mm
		97739 SCNNA_MOUSE (1-665): 0: 666: 82.66		E9PXB7_MOUSE (122-975): 0: 870: 95.79
+	Hs
		788518 SCNNA_HUMAN (1-669): 0: 734: 100.00		NEDD4_HUMAN (100-975): 0: 801: 61.35
+	Hs
		788540 SCNNA_HUMAN (1-669): 0: 734: 100.00		ITCH_HUMAN (9-972): 0: 795: 32.96
+	Hs
		788545 SCNNA_HUMAN (1-669): 0: 734: 100.00		WWP1_HUMAN (1-972): 0: 787: 32.96
+	Rn
		788562 SCNNA_RAT (1-668): 0: 685: 82.74		NEDD4_RAT (13-975): 0: 808: 55.39
+	Mm
		861878 SCNNA_MOUSE (1-665): 0: 666: 82.66		NEDD4_MOUSE (12-975): 0: 808: 55.08
+	Hs
		131774 SCNNA_HUMAN (1-669): 0: 734: 100.00		WWP2_HUMAN (213-972): 0: 732: 36.95
+	Mm
		97756 SCNNG_MOUSE (36-650): 0: 580: 33.12		E9PXB7_MOUSE (122-975): 0: 870: 95.79
+	Mm
		861906 SCNNG_MOUSE (36-650): 0: 580: 33.12		NEDD4_MOUSE (12-975): 0: 808: 55.08
+	Rn
		788568 SCNNG_RAT (36-650): 0: 573: 32.75		NEDD4_RAT (13-975): 0: 808: 55.39
+	Rn
		788565 SCNNB_RAT (54-666): 0: 570: 31.06		NEDD4_RAT (13-975): 0: 808: 55.39
+	Hs
		861522 SCNNG_HUMAN (36-650): 0: 573: 33.44		NEDD4_HUMAN (100-975): 0: 801: 61.35
+	Hs
		861521 SCNNB_HUMAN (54-666): 0: 569: 30.38		NEDD4_HUMAN (100-975): 0: 801: 61.35
+	Rn
		788567 SCNNG_RAT (36-650): 0: 573: 32.75		Q4V8H7_RAT (1-972): 0: 792: 33.50
+	Hs
		131834 SCNNG_HUMAN (36-650): 0: 573: 33.44		WWP2_HUMAN (213-972): 0: 732: 36.95
+	Hs
		131833 SCNNB_HUMAN (54-666): 0: 569: 30.38		WWP2_HUMAN (213-972): 0: 732: 36.95
+	Hs
		788534 SCNNA_HUMAN (1-669): 0: 734: 100.00		HUWE1_HUMAN (522-973): 2.79e-163: 534: 41.27
+	Hs
		788533 SCNNA_HUMAN (1-669): 0: 734: 100.00		HECW1_HUMAN (112-640): 1.65e-18: 93.8: 13.33
+	Hs
		902323 SCNNB_HUMAN (54-666): 0: 569: 30.38		HECW1_HUMAN (112-640): 1.65e-18: 93.8: 13.33