HitPredict

Interactor 1: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Interactor 2: MGA2 (P40578)
Protein MGA2
Gene: MGA2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	15466864, 17719829, 12867034, 26508657, 19153599, 17289586
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~HECT
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 809 Sc			1 1113
+	Sc
		764189 RSP5_YEAST (1-809): 0: 813: 100.00		SPT23_YEAST (128-1113): 0: 633: 37.33
+	Hs
		132021 WWP2_HUMAN (92-809): 0: 686: 40.00		ASPP2_HUMAN (339-787): 1.42e-72: 264: 14.29
+	Hs
		861599 NEDD4_HUMAN (101-807): 0: 670: 39.95		ASPP2_HUMAN (339-787): 1.42e-72: 264: 14.29
+	Hs
		861581 NEDD4_HUMAN (101-807): 0: 670: 39.95		Q05BL1_HUMAN (339-787): 7.98e-72: 261: 14.29
+	Hs
		132166 WWP2_HUMAN (92-809): 0: 686: 40.00		ANR44_HUMAN (551-886): 1.59e-54: 208: 11.47
+	Hs
		131616 WWP2_HUMAN (92-809): 0: 686: 40.00		ANR17_HUMAN (601-937): 6.95e-51: 199: 12.10
+	Hs
		1439007 SMUF1_HUMAN (4-809): 0: 693: 36.28		ANR50_HUMAN (701-956): 3.58e-48: 190: 15.25
+	Hs
		131630 WWP2_HUMAN (92-809): 0: 686: 40.00		PSD10_HUMAN (623-796): 2e-33: 130: 14.42
+	Hs
		861588 NEDD4_HUMAN (101-807): 0: 670: 39.95		ANK3_HUMAN (675-864): 6.07e-14: 79.1: 16.24
+	Hs
		1280328 HUWE1_HUMAN (276-808): 8.57e-171: 549: 33.22		ANKH1_HUMAN (608-937): 3.43e-50: 197: 13.43
+	Hs
		1280343 HUWE1_HUMAN (276-808): 8.57e-171: 549: 33.22		ANR52_HUMAN (299-841): 1.29e-45: 181: 10.87
+	Hs
		1115588 ITCH_HUMAN (1-445): 8.33e-32: 135: 16.59		ASPP2_HUMAN (339-787): 1.42e-72: 264: 14.29