HitPredict

Interactor 1: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Interactor 2: Q7K148 (Q7K148)
Proteasome subunit beta
Gene: Prosbeta5

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	23457214, 23738891, 31002009, 22036573, 19079254, 38944040
Identification Methods	affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Dm			1 282
+	Hs
		700432 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB8_HUMAN (1-277): 5.11e-103: 303: 48.74
+	Dm
		1264669 PSA5_DROME (1-233): 1.18e-97: 286: 30.71		Q7K148_DROME (1-282): 5.99e-99: 292: 100.00
+	Sp
		314462 PSA2_SCHPO (3-233): 1.97e-107: 311: 58.20		PSA3_SCHPO (43-278): 4.9e-88: 264: 16.60
+	Hs
		700556 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSA5_HUMAN (40-272): 3.49e-90: 269: 18.52
+	Hs
		700559 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB5_HUMAN (1-277): 1.25e-88: 266: 51.63
+	Hs
		681576 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSA4_HUMAN (43-269): 1.68e-85: 258: 17.30
+	Hs
		165267 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSA7_HUMAN (46-270): 9.36e-85: 255: 15.88
+	Hs
		700571 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB10_HUMAN (47-256): 1.79e-83: 253: 29.05
+	Sp
		721233 PSA5_SCHPO (1-231): 2.83e-100: 293: 32.77		PSB5_SCHPO (42-277): 1.19e-79: 243: 52.97
+	Ce
		1176684 PSA2_CAEEL (4-233): 3.62e-99: 289: 60.35		PBS5_CAEEL (44-276): 5.34e-79: 242: 45.00
+	Mt
		203444 PSA_METTH (1-233): 1.54e-102: 298: 36.17		PSB_METTH (72-267): 9.38e-75: 228: 36.04
+	Dm
		1376951 PSA5_DROME (1-233): 1.18e-97: 286: 30.71		Q9W470_DROME (47-267): 1.25e-77: 239: 28.51
+	Hs
		700692 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSMA8_HUMAN (43-269): 4.69e-76: 233: 17.08
+	Hs
		700714 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB7_HUMAN (39-265): 2.89e-75: 232: 28.63
+	Dm
		1376942 PSA5_DROME (1-233): 1.18e-97: 286: 30.71		Q9VUJ1_DROME (47-267): 5.17e-75: 231: 27.60
+	Hs
		700558 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB6_HUMAN (69-259): 1.62e-73: 226: 30.21
+	Mm
		1236011 PSA_METMP (4-233): 7.12e-99: 290: 34.05		PSB_METMP (69-265): 1.31e-71: 221: 31.66
+	Ph
		237460 PSA_PYRHO (4-231): 1.42e-101: 296: 41.74		PSB1_PYRHO (68-256): 3.03e-20: 87.8: 30.53
+	Hs
		700494 PSA5_HUMAN (1-233): 1.1e-98: 288: 31.38		PSB9_HUMAN (73-256): 2.24e-19: 85.9: 30.98
+	Dm
		47775 PSA5_DROME (1-233): 1.18e-97: 286: 30.71		A0AQH0_DROME (73-256): 1.52e-18: 84: 29.57