HitPredict

Interactor 1: PSB9 (P28065)
Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)
Gene: PSMB9

Interactor 2: PSA5 (P28066)
Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain)
Gene: PSMA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	26186194, 28514442, 30833792, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Hs			1 241
+	Hs
		700556 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSA5_HUMAN (1-241): 1.06e-107: 312: 100.00
+	Hs
		700432 PSB8_HUMAN (10-219): 6.31e-75: 229: 29.38		PSA5_HUMAN (1-241): 1.06e-107: 312: 100.00
+	Dm
		47775 A0AQH0_DROME (7-212): 1.17e-77: 234: 51.21		PSA5_DROME (1-241): 1.01e-103: 302: 70.37
+	Dm
		47749 A0AQH0_DROME (7-212): 1.17e-77: 234: 51.21		PSA2_DROME (3-241): 1.56e-99: 291: 31.38
+	Dm
		821867 PSA5_DROME (5-218): 2.7e-76: 231: 16.96		PSA2_DROME (3-241): 1.56e-99: 291: 31.38
+	Sc
		735924 PSB1_YEAST (13-212): 7.85e-77: 232: 45.27		PSA5_YEAST (1-241): 5.66e-95: 280: 60.49
+	Hv
		1463044 PSA1_HALVD (5-218): 3.27e-75: 229: 17.49		PSA1_HALVD (5-240): 4.12e-93: 275: 40.51
+	Hs
		165267 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSA7_HUMAN (8-239): 5.33e-89: 265: 36.17
+	Hs
		680778 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSA1_HUMAN (3-241): 7.76e-89: 265: 28.81
+	Hs
		681107 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSA2_HUMAN (3-241): 2.39e-89: 265: 30.96
+	Ss
		99238 F2Z5K2_PIG (5-219): 4.73e-79: 238: 17.90		F2Z5L7_PIG (3-241): 7.76e-89: 265: 28.81
+	Hs
		700596 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSA6_HUMAN (4-241): 1.52e-88: 263: 25.93
+	Hs
		165265 PSB8_HUMAN (10-219): 6.31e-75: 229: 29.38		PSA7_HUMAN (8-239): 5.33e-89: 265: 36.17
+	Hs
		680776 PSB8_HUMAN (10-219): 6.31e-75: 229: 29.38		PSA1_HUMAN (3-241): 7.76e-89: 265: 28.81
+	Hs
		681105 PSB8_HUMAN (10-219): 6.31e-75: 229: 29.38		PSA2_HUMAN (3-241): 2.39e-89: 265: 30.96
+	Hs
		700448 PSB8_HUMAN (10-219): 6.31e-75: 229: 29.38		PSA6_HUMAN (4-241): 1.52e-88: 263: 25.93
+	Hs
		700692 PSA5_HUMAN (5-219): 4.73e-79: 238: 17.90		PSMA8_HUMAN (6-235): 3.21e-44: 150: 37.24
+	Sp
		1082946 PSA5_SCHPO (5-219): 1.4e-78: 237: 19.57		PSA4_SCHPO (6-241): 6.85e-44: 150: 34.03
+	Sc
		661403 PSB1_YEAST (13-212): 7.85e-77: 232: 45.27		PSA3_YEAST (8-238): 3.61e-44: 150: 36.40
+	Sp
		314462 PSA3_SCHPO (5-219): 9.54e-75: 227: 15.28		PSA2_SCHPO (7-241): 1e-44: 151: 35.22