HitPredict

Interactor 1: MPIP2 (P48966)
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Gene: Cdc25b

Interactor 2: CDK5 (Q03114)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22899714
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 574 Rn			1 292
+	Hs
		625159 MPIP2_HUMAN (1-574): 0: 745: 79.48		CDK2_HUMAN (1-292): 3.89e-144: 408: 59.39
+	Hs
		673468 MPIP2_HUMAN (1-574): 0: 745: 79.48		CDK3_HUMAN (1-291): 8.83e-142: 402: 61.30
+	Hs
		673469 MPIP2_HUMAN (1-574): 0: 745: 79.48		CDK5_HUMAN (1-292): 1.02e-139: 397: 99.32
+	Hs
		414768 MPIP2_HUMAN (1-574): 0: 745: 79.48		CDK1_HUMAN (1-289): 2e-135: 386: 56.01
+	Hs
		673470 MPIP2_HUMAN (1-574): 0: 745: 79.48		CDK16_HUMAN (1-286): 8.8e-115: 341: 57.64
+	Hs
		625158 MPIP1_HUMAN (40-572): 0: 593: 41.70		CDK2_HUMAN (1-292): 3.89e-144: 408: 59.39
+	Hs
		673388 MPIP1_HUMAN (40-572): 0: 593: 41.70		CDK3_HUMAN (1-291): 8.83e-142: 402: 61.30
+	Hs
		673389 MPIP1_HUMAN (40-572): 0: 593: 41.70		CDK5_HUMAN (1-292): 1.02e-139: 397: 99.32
+	Hs
		414767 MPIP1_HUMAN (40-572): 0: 593: 41.70		CDK1_HUMAN (1-289): 2e-135: 386: 56.01
+	Rn
		823140 MPIP1_RAT (39-572): 0: 566: 40.48		CDK5_RAT (1-292): 6.5e-139: 395: 100.00
+	Hs
		625160 MPIP3_HUMAN (205-571): 5.29e-127: 382: 37.93		CDK2_HUMAN (1-292): 3.89e-144: 408: 59.39
+	Hs
		673567 MPIP3_HUMAN (205-571): 5.29e-127: 382: 37.93		CDK5_HUMAN (1-292): 1.02e-139: 397: 99.32
+	Hs
		414769 MPIP3_HUMAN (205-571): 5.29e-127: 382: 37.93		CDK1_HUMAN (1-289): 2e-135: 386: 56.01
+	Rn
		89020 D4ADT2_RAT (207-571): 2.94e-104: 323: 35.64		CDK5_RAT (1-292): 6.5e-139: 395: 100.00
+	Mm
		509473 MPIP3_MOUSE (334-571): 5.09e-100: 312: 44.90		CDK1_MOUSE (1-289): 3.97e-134: 383: 56.70
+	Dm
		618386 TWINE_DROME (264-558): 1.47e-102: 318: 35.53		CDK1_DROME (1-287): 2.15e-130: 373: 56.40
+	Sp
		383444 MPIP_SCHPO (285-546): 2.48e-86: 281: 33.71		CDK1_SCHPO (1-290): 6.01e-128: 367: 52.01
+	Sc
		339449 MPIP_YEAST (406-564): 6.02e-54: 193: 38.37		CDK1_YEAST (1-288): 4.58e-124: 357: 55.10