HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	33961781, 36931259, 15324660, 17353931, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032880 - regulation of protein localization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1118 Hs			1 247
+	Hs
		828195 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		828203 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Mm
		972256 UBP8_MOUSE (1-1118): 0: 775: 80.77		1433E_MOUSE (1-244): 2.03e-141: 398: 63.53
+	Hs
		729655 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		828197 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		690802 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		730427 UBP8_HUMAN (1-1118): 0: 825: 100.00		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		967028 UBP22_HUMAN (744-1109): 2.8e-109: 353: 26.73		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		1049912 UBP22_HUMAN (744-1109): 2.8e-109: 353: 26.73		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		967138 UBP46_HUMAN (764-1109): 1.74e-105: 337: 27.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		966166 UBP46_HUMAN (764-1109): 1.74e-105: 337: 27.00		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		275881 UBP12_HUMAN (764-1110): 4.8e-105: 336: 27.47		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		972110 UBP21_HUMAN (566-1111): 2.13e-98: 325: 23.85		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		967143 UBP46_HUMAN (764-1109): 1.74e-105: 337: 27.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		275886 UBP12_HUMAN (764-1110): 4.8e-105: 336: 27.47		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Hs
		966999 UBP21_HUMAN (566-1111): 2.13e-98: 325: 23.85		1433G_HUMAN (1-247): 3.17e-139: 392: 100.00
+	Hs
		691542 UBP22_HUMAN (744-1109): 2.8e-109: 353: 26.73		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		729723 UBP46_HUMAN (764-1109): 1.74e-105: 337: 27.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		275874 UBP12_HUMAN (764-1110): 4.8e-105: 336: 27.47		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		967140 UBP46_HUMAN (764-1109): 1.74e-105: 337: 27.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59