HitPredict

Interactor 1: GSK3A (P49840)
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene: GSK3A

Interactor 2: FBX42 (Q6P3S6)
F-box only protein 42 (Just one F-box and Kelch domain-containing protein)
Gene: FBXO42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.50	0.655

Property	Details
Experiments	30824926, 36779422, 28514442, 33961781, 38580884
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 717
+	Hs
		835835 GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41		FBX42_HUMAN (1-717): 0: 603: 100.00
+	At
		1105840 KSG7_ARATH (82-459): 8.13e-154: 444: 59.89		BSL2_ARATH (8-694): 4.42e-99: 329: 17.50
+	At
		1105837 KSG7_ARATH (82-459): 8.13e-154: 444: 59.89		BSL3_ARATH (112-694): 4.35e-90: 304: 17.97
+	At
		1013374 KSG7_ARATH (82-459): 8.13e-154: 444: 59.89		Q0WWX4_ARATH (41-499): 2.67e-65: 231: 17.08
+	Hs
		835367 GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00		KEAP1_HUMAN (4-181): 1.55e-32: 135: 12.92
+	At
		794943 KSG3_ARATH (59-449): 3.98e-149: 433: 58.78		ADO3_ARATH (49-361): 1e-33: 139: 22.77
+	At
		1105597 KSG7_ARATH (82-459): 8.13e-154: 444: 59.89		BSL1_ARATH (4-314): 4.54e-28: 122: 13.33
+	Hs
		835743 GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41		KEAP1_HUMAN (4-181): 1.55e-32: 135: 12.92
+	Hs
		836136 GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41		NS1BP_HUMAN (274-539): 1.03e-23: 108: 10.43
+	Hs
		625250 CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03		HCFC1_HUMAN (8-265): 3.09e-22: 105: 13.99