Protein: PTH2R
Parathyroid hormone 2 receptor (PTH2 receptor)

Gene: PTH2R
Organism: Homo sapiens
Interactions: 138
UniProt ID: P49190

Gene Ontology (top 5):
GO:0004991 - parathyroid hormone receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880152

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

4

High-throughput

0.691

High

880173

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.691

High

377265

PTHY
Parathyroid hormone

1

1

Small-scale

0.647

High

880161

WDR59
GATOR2 complex protein WDR59

1

0

High-throughput

0.578

High

564808

NCAM1
Neural cell adhesion molecule 1

2

0

High-throughput

0.576

High

880147

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

6

High-throughput

0.549

High

880154

ACD10
Acyl-CoA dehydrogenase family member 10

2

3

High-throughput

0.549

High

880155

MZT2B
Mitotic-spindle organizing protein 2B

2

3

High-throughput

0.549

High

141910

PODXL
Podocalyxin

1

1

High-throughput

0.536

High

178619

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

1

High-throughput

0.536

High

256009

S19A2
Thiamine transporter 1

1

5

High-throughput

0.536

High

648459

FGFR4
Fibroblast growth factor receptor 4

1

10

High-throughput

0.536

High

658660

JAK1
Tyrosine-protein kinase JAK1

1

10

High-throughput

0.536

High

761189

RYK
Tyrosine-protein kinase RYK

1

12

High-throughput

0.536

High

880121

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.536

High

880122

KNTC1
Kinetochore-associated protein 1

1

1

High-throughput

0.536

High

880129

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.536

High

880133

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.536

High

880166

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.536

High

880167

LRP10
Low-density lipoprotein receptor-related protein 10

1

1

High-throughput

0.536

High

880178

SFXN5
Sideroflexin-5

1

1

High-throughput

0.536

High

880180

CTR3
Cationic amino acid transporter 3

1

10

High-throughput

0.536

High

880184

S47A1
Multidrug and toxin extrusion protein 1

1

1

High-throughput

0.536

High

880186

KIRR1
Kin of IRRE-like protein 1

1

2

High-throughput

0.536

High

880196

SGPP1
Sphingosine-1-phosphate phosphatase 1

1

2

High-throughput

0.536

High

880198

ULBP3
UL16-binding protein 3

1

3

High-throughput

0.536

High

880205

JPH1
Junctophilin-1

1

1

High-throughput

0.536

High

880221

S39AA
Zinc transporter ZIP10

1

11

High-throughput

0.536

High

880224

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.536

High

880206

HM20A
High mobility group protein 20A

1

1

High-throughput

0.523

High

271684

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

536737

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

562786

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

880125

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

880140

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.513

High

880169

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.513

High

880185

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

880193

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.513

High

880212

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.513

High

173681

BTAF1
TATA-binding protein-associated factor 172

1

4

High-throughput

0.489

High

249833

STX10
Syntaxin-10

1

2

High-throughput

0.489

High

252841

EXOC3
Exocyst complex component 3

1

2

High-throughput

0.489

High

403908

GCR
Glucocorticoid receptor

1

4

High-throughput

0.489

High

408003

TBB4A
Tubulin beta-4A chain

1

3

High-throughput

0.489

High

431396

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

2

High-throughput

0.489

High

665079

COT2
COUP transcription factor 2

1

3

High-throughput

0.489

High

698484

CALX
Calnexin

1

5

High-throughput

0.489

High

755534

TTK
Dual specificity protein kinase TTK

1

3

High-throughput

0.489

High

771570

HXD13
Homeobox protein Hox-D13

1

1

High-throughput

0.489

High

880127

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.489

High

880128

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.489

High

880135

ATM
Serine-protein kinase ATM

1

6

High-throughput

0.489

High

880136

MTX1
Metaxin-1

1

4

High-throughput

0.489

High

880137

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.489

High

880139

PDE7A
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

1

1

High-throughput

0.489

High

880142

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.489

High

880145

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.489

High

880146

ORML2
ORM1-like protein 2

1

1

High-throughput

0.489

High

880149

MTX3
Metaxin-3

1

4

High-throughput

0.489

High

880150

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

880151

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

High-throughput

0.489

High

880153

ATLA3
Atlastin-3

1

3

High-throughput

0.489

High

880157

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.489

High

880158

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

2

High-throughput

0.489

High

880160

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.489

High

880162

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.489

High

880163

HACD2
Very-long-chain

1

3

High-throughput

0.489

High

880164

CERS6
Ceramide synthase 6

1

8

High-throughput

0.489

High

880170

VRK2
Serine/threonine-protein kinase VRK2

1

2

High-throughput

0.489

High

880171

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.489

High

880174

GUF1
Translation factor GUF1, mitochondrial

1

1

High-throughput

0.489

High

880175

NAV1
Neuron navigator 1

1

1

High-throughput

0.489

High

880187

RBM14
RNA-binding protein 14

1

1

High-throughput

0.489

High

880188

GCP5
Gamma-tubulin complex component 5

1

3

High-throughput

0.489

High

880191

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

880199

ELOV4
Very long chain fatty acid elongase 4

1

6

High-throughput

0.489

High

880201

INT2
Integrator complex subunit 2

1

2

High-throughput

0.489

High

880202

SG196
Protein O-mannose kinase

1

3

High-throughput

0.489

High

880203

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

2

High-throughput

0.489

High

880214

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.489

High

880218

IPO11
Importin-11

1

7

High-throughput

0.489

High

880222

ZN281
Zinc finger protein 281

1

2

High-throughput

0.489

High

880223

TMX2
Thioredoxin-related transmembrane protein 2

1

2

High-throughput

0.489

High

603888

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.445

High

749600

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

2

High-throughput

0.445

High

787361

TGFR1
TGF-beta receptor type-1

1

1

High-throughput

0.445

High

880134

PTK7
Inactive tyrosine-protein kinase 7

1

6

High-throughput

0.445

High

880189

OSMR
Oncostatin-M-specific receptor subunit beta

1

1

High-throughput

0.445

High

880177

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.426

High

184975

SPTC2
Serine palmitoyltransferase 2

1

1

High-throughput

0.407

High

880168

WAPL
Wings apart-like protein homolog

1

1

High-throughput

0.407

High

880172

LMTK2
Serine/threonine-protein kinase LMTK2

1

13

High-throughput

0.407

High

880208

SPTC3
Serine palmitoyltransferase 3

1

1

High-throughput

0.407

High

880210

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.407

High

880217

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.407

High

880126

DYLT1
Dynein light chain Tctex-type 1

2

0

High-throughput

0.316

High

880213

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.282

High

66159

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.279

Low

212874

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.279

Low

219934

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

328232

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

732805

GLPK
Glycerol kinase

1

0

High-throughput

0.279

Low

868072

AL1A3
Retinaldehyde dehydrogenase 3

1

0

High-throughput

0.279

Low

880123

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

880131

RN5A
2-5A-dependent ribonuclease

1

0

High-throughput

0.279

Low

880132

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.279

Low

880143

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

880144

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.279

Low

880156

MTFR2
Mitochondrial fission regulator 2

1

0

High-throughput

0.279

Low

880159

INT5
Integrator complex subunit 5

1

0

High-throughput

0.279

Low

880176

TTC8
Tetratricopeptide repeat protein 8

1

0

High-throughput

0.279

Low

880179

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.279

Low

880181

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.279

Low

880182

ATG2B
Autophagy-related protein 2 homolog B

1

0

High-throughput

0.279

Low

880183

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.279

Low

880190

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.279

Low

880192

APOL2
Apolipoprotein L2

1

0

High-throughput

0.279

Low

880194

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

880195

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.279

Low

880197

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.279

Low

880204

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.279

Low

880209

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.279

Low

880211

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.279

Low

880215

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.279

Low

880219

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

880220

NOCT
Nocturnin

1

0

High-throughput

0.279

Low

880225

PEX16
Peroxisomal membrane protein PEX16

1

0

High-throughput

0.279

Low

165761

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.249

Low

880124

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

880141

ARHG6
Rho guanine nucleotide exchange factor 6

1

0

High-throughput

0.249

Low

193365

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

High-throughput

0.232

Low

880130

ACY1
Aminoacylase-1

1

0

High-throughput

0.232

Low

880138

NCOA4
Nuclear receptor coactivator 4

1

0

High-throughput

0.232

Low

880148

TM177
Transmembrane protein 177

1

0

High-throughput

0.232

Low

880165

RBPS2
RNA-binding protein with multiple splicing 2

1

0

High-throughput

0.232

Low

880200

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.232

Low

880207

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.232

Low

880216

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025