HitPredict

Interactor 1: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Interactor 2: EZ (P42124)
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)
Gene: E(z)

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 12697833, 12408864
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ezh2_MCSS~PRC2_HTH_1, Ezh2_MCSS~SET, PRC2_HTH_1~PRC2_HTH_1, preSET_CXC~preSET_CXC, SET~preSET_CXC, SET~SET
Common GO terms GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
and 17 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 760
Dm

1 760
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Zm
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025