HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 27634302, 30779601, 34591612, 36517590, 19026781, 24981860, 33961781, 19026780, unassigned3799
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ezh2_MCSS~PRC2_HTH_1, Ezh2_MCSS~SET, PRC2_HTH_1~PRC2_HTH_1, preSET_CXC~preSET_CXC, SET~preSET_CXC, SET~SET
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 10 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 746
Hs

1 747
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+ At
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Last updated: 11Aug2025