HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29764989
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 156 Hs			1 603
+	Hs
		919920 ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94		PLK1_HUMAN (1-603): 0: 619: 100.00
+	Hs
		274124 ANR17_HUMAN (69-147): 2.29e-19: 85.5: 20.25		PLK1_HUMAN (1-603): 0: 619: 100.00
+	Hs
		920321 RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21		PLK1_HUMAN (1-603): 0: 619: 100.00
+	Hs
		920118 ANR44_HUMAN (3-76): 1.63e-10: 60: 19.23		PLK1_HUMAN (1-603): 0: 619: 100.00
+	Hs
		177189 ANR28_HUMAN (85-155): 1.33e-09: 57.3: 16.90		PLK1_HUMAN (1-603): 0: 619: 100.00
+	Hs
		1331015 ANR44_HUMAN (3-76): 1.63e-10: 60: 19.23		PLK2_HUMAN (38-587): 1.05e-163: 485: 36.53
+	Hs
		177318 ANR28_HUMAN (85-155): 1.33e-09: 57.3: 16.90		PLK2_HUMAN (38-587): 1.05e-163: 485: 36.53
+	Hs
		169998 CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00		AURKA_HUMAN (28-307): 4.41e-43: 160: 32.17
+	Hs
		136047 POTEI_HUMAN (49-152): 1.9e-19: 85.8: 13.89		PLK4_HUMAN (56-306): 2.19e-55: 204: 37.70
+	Hs
		170289 EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37		AURKA_HUMAN (28-307): 4.41e-43: 160: 32.17