HitPredict

Interactor 1: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	33504946, 35468939, 21145461
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 156 Hs			1 745
+	Hs
		842748 CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00		CUL1_HUMAN (6-745): 0: 770: 36.24
+	Hs
		842750 CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1091394 ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94		CUL4A_HUMAN (4-745): 0: 770: 26.86
+	Hs
		1091393 ANK3_HUMAN (3-153): 3.24e-36: 133: 16.94		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		592933 ANK1_HUMAN (3-130): 9.05e-35: 129: 24.81		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1114326 EHMT1_HUMAN (15-147): 1.06e-33: 126: 25.00		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		943938 RIPK4_HUMAN (7-107): 5.52e-26: 104: 22.55		CUL1_HUMAN (6-745): 0: 770: 36.24
+	Hs
		1114018 EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1115433 ASB8_HUMAN (60-153): 2.4e-19: 83.4: 21.28		CUL4B_HUMAN (4-745): 0: 767: 27.79
+	Hs
		1114046 ANR27_HUMAN (2-85): 1.33e-16: 77.7: 21.59		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1114236 TANC1_HUMAN (56-154): 1.19e-14: 71.9: 21.00		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		920438 DAPK1_HUMAN (69-155): 1.65e-14: 71.5: 24.14		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1115108 RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21		CUL4A_HUMAN (4-745): 0: 770: 26.86
+	Hs
		295498 PSD10_HUMAN (1-85): 4.42e-13: 65.7: 22.73		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1113853 ASB13_HUMAN (80-147): 2.2e-11: 62: 23.53		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		62950 POTEF_HUMAN (82-149): 1.91e-10: 60: 21.13		CUL3_HUMAN (1-745): 0: 763: 26.38
+	Hs
		1361052 ASB15_HUMAN (16-136): 6.73e-42: 148: 33.07		CUL5_HUMAN (7-745): 0: 628: 26.69
+	Hs
		1371866 ASB8_HUMAN (60-153): 2.4e-19: 83.4: 21.28		CUL5_HUMAN (7-745): 0: 628: 26.69
+	Hs
		1371859 TNKS2_HUMAN (8-136): 1.51e-11: 63.2: 21.05		CUL5_HUMAN (7-745): 0: 628: 26.69
+	Hs
		1361058 ASB13_HUMAN (80-147): 2.2e-11: 62: 23.53		CUL5_HUMAN (7-745): 0: 628: 26.69