HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: ASB8 (Q9H765)
Ankyrin repeat and SOCS box protein 8 (ASB-8)
Gene: ASB8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	31253590, 26186194, 28514442, 33961781, 24337577
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Cullin, Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 288
+	Hs
		1360793 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB11_HUMAN (8-286): 2.16e-66: 211: 25.53
+	Hs
		1371913 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB1_HUMAN (21-286): 4.28e-55: 183: 26.89
+	Hs
		1371865 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB7_HUMAN (20-287): 1.02e-54: 181: 24.19
+	Hs
		920438 CUL3_HUMAN (8-780): 0: 753: 22.96		DAPK1_HUMAN (15-277): 2.08e-63: 217: 21.72
+	Hs
		1091393 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK3_HUMAN (59-287): 2.02e-56: 197: 23.41
+	Hs
		1112713 CUL1_HUMAN (11-780): 0: 746: 27.84		Q9H4D1_HUMAN (25-287): 3.66e-51: 181: 23.31
+	Hs
		1361058 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB13_HUMAN (13-154): 1.64e-35: 130: 34.97
+	Hs
		1113629 CUL3_HUMAN (8-780): 0: 753: 22.96		ANKH1_HUMAN (7-177): 8.66e-40: 149: 28.74
+	Hs
		592933 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK1_HUMAN (92-287): 4.22e-39: 147: 17.81
+	Hs
		1371828 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB9_HUMAN (19-155): 3.56e-25: 103: 28.26
+	Hs
		1113853 CUL3_HUMAN (8-780): 0: 753: 22.96		ASB13_HUMAN (13-154): 1.64e-35: 130: 34.97
+	Hs
		1371859 CUL5_HUMAN (1-780): 0: 791: 100.00		TNKS2_HUMAN (1-102): 5.78e-20: 91.7: 21.36
+	Hs
		295498 CUL3_HUMAN (8-780): 0: 753: 22.96		PSD10_HUMAN (114-255): 9.04e-28: 108: 26.19
+	Hs
		1359846 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB5_HUMAN (7-111): 4.54e-11: 64.4: 26.67
+	Hs
		177215 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR28_HUMAN (1-139): 6.25e-19: 88.6: 26.03
+	Hs
		1114236 CUL3_HUMAN (8-780): 0: 753: 22.96		TANC1_HUMAN (38-213): 3.42e-17: 83.6: 34.69
+	Hs
		1114326 CUL3_HUMAN (8-780): 0: 753: 22.96		EHMT1_HUMAN (155-286): 7.04e-17: 82.5: 17.16
+	Hs
		943938 CUL1_HUMAN (11-780): 0: 746: 27.84		RIPK4_HUMAN (1-82): 1.53e-13: 72.5: 19.51
+	Hs
		1114046 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR27_HUMAN (76-192): 1.35e-10: 63.9: 34.75
+	Hs
		1113407 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR54_HUMAN (76-188): 3.05e-09: 58.5: 36.28