HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16007099
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 464
+	Hs
		842942 CDN2C_HUMAN (1-168): 3.74e-53: 167: 100.00		MK08_HUMAN (39-464): 1.27e-162: 467: 90.87
+	Hs
		842697 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		MK10_HUMAN (1-464): 0: 518: 100.00
+	Hs
		842681 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		MK08_HUMAN (39-464): 1.27e-162: 467: 90.87
+	Hs
		668052 RAI14_HUMAN (1-135): 1.92e-37: 137: 21.32		CDK2_HUMAN (61-365): 9.78e-137: 396: 34.41
+	Hs
		842771 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		MK14_HUMAN (42-408): 5.52e-134: 392: 45.95
+	Mm
		867756 MIB1_MOUSE (74-168): 2.22e-14: 71.5: 21.88		MK14_MOUSE (42-408): 2.72e-134: 393: 45.95
+	Hs
		703478 CDN2C_HUMAN (1-168): 3.74e-53: 167: 100.00		MK01_HUMAN (58-397): 8.75e-85: 266: 42.98
+	Hs
		703517 CDN2D_HUMAN (6-159): 4.02e-48: 155: 45.81		MK01_HUMAN (58-397): 8.75e-85: 266: 42.98
+	Hs
		691686 DAPK1_HUMAN (42-168): 7.96e-30: 116: 20.93		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		703511 DAPK1_HUMAN (42-168): 7.96e-30: 116: 20.93		MK01_HUMAN (58-397): 8.75e-85: 266: 42.98
+	Rn
		989666 CSKI1_RAT (1-159): 6.19e-30: 116: 14.69		MK01_RAT (53-397): 1.25e-84: 266: 42.37
+	Hs
		691658 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		703476 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		MK01_HUMAN (58-397): 8.75e-85: 266: 42.98
+	Hs
		703477 CDN2B_HUMAN (9-122): 1.24e-20: 84: 45.22		MK01_HUMAN (58-397): 8.75e-85: 266: 42.98
+	Rn
		989653 TANC1_RAT (82-168): 3.17e-12: 65.3: 22.47		MK01_RAT (53-397): 1.25e-84: 266: 42.37