Protein: MPIP1
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)

Gene: MPIP1, CDC25A
Organism: Homo sapiens
Interactions: 126
UniProt ID: P30304

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154136

CHK1
Serine/threonine-protein kinase Chk1

9

3

Small-scale

0.973

High

331222

CHK2
Serine/threonine-protein kinase Chk2

6

4

Small-scale

0.952

High

625158

CDK2
Cyclin-dependent kinase 2

5

18

Small-scale

0.912

High

373753

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

5

Small-scale

0.866

High

673446

FBW1A
F-box/WD repeat-containing protein 1A

18

7

Small-scale

0.766

High

673442

FBW1B
F-box/WD repeat-containing protein 11

16

7

Small-scale

0.764

High

673432

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

Small-scale

0.740

High

673382

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.736

High

673383

SKP1
S-phase kinase-associated protein 1

6

1

Small-scale

0.730

High

673398

CUL1
Cullin-1

6

3

Small-scale

0.724

High

507543

PIM1
Serine/threonine-protein kinase pim-1

1

4

Small-scale

0.724

High

673381

1433E
14-3-3 protein epsilon

5

9

Small-scale

0.719

High

673390

1433F
14-3-3 protein eta

5

20

High-throughput

0.714

High

673365

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.705

High

673415

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

2

High-throughput

0.698

High

673428

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.698

High

646655

1433T
14-3-3 protein theta

4

20

Small-scale

0.697

High

673380

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

673395

DUS8
Dual specificity protein phosphatase 8

1

3

High-throughput

0.656

High

673444

FZR1
Fizzy-related protein homolog

3

2

Small-scale

0.656

High

673371

NAA10
N-alpha-acetyltransferase 10

2

1

Small-scale

0.654

High

624548

CCNE1
G1/S-specific cyclin-E1

3

11

Small-scale

0.651

High

538480

CCNB1
G2/mitotic-specific cyclin-B1

3

9

Small-scale

0.650

High

673373

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.647

High

673374

MAPK2
MAP kinase-activated protein kinase 2

1

2

Small-scale

0.647

High

673389

CDK5
Cyclin-dependent kinase 5

1

18

Small-scale

0.647

High

673396

ROCK1
Rho-associated protein kinase 1

1

1

Small-scale

0.647

High

673406

MK14
Mitogen-activated protein kinase 14

1

12

Small-scale

0.647

High

673392

EP300
Histone acetyltransferase p300

2

1

Small-scale

0.624

High

148433

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.618

High

414767

CDK1
Cyclin-dependent kinase 1

1

18

High-throughput

0.618

High

658804

MK01
Mitogen-activated protein kinase 1

1

5

High-throughput

0.618

High

673363

MPIP1
M-phase inducer phosphatase 1

1

3

High-throughput

0.618

High

673364

MPIP3
M-phase inducer phosphatase 3

1

3

Small-scale

0.618

High

673388

CDK3
Cyclin-dependent kinase 3

1

18

High-throughput

0.618

High

673408

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.618

High

673431

TRIB3
Tribbles homolog 3

1

1

Small-scale

0.618

High

673409

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.614

High

673433

NAA11
N-alpha-acetyltransferase 11

2

1

High-throughput

0.606

High

305154

UBE4B
Ubiquitin conjugation factor E4 B

2

0

High-throughput

0.602

High

673387

SMAD3
Mothers against decapentaplegic homolog 3

2

0

Small-scale

0.588

High

673426

AURKB
Aurora kinase B

1

0

High-throughput

0.586

High

673386

CCNA1
Cyclin-A1

2

8

Small-scale

0.584

High

673401

FHL1
Four and a half LIM domains protein 1

2

5

Small-scale

0.584

High

673438

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

1

High-throughput

0.584

High

337996

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.578

High

673425

HDA11
Histone deacetylase 11

1

3

Small-scale

0.578

High

671723

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.554

High

162429

XPO1
Exportin-1

1

4

High-throughput

0.541

High

638229

RBTN2
Rhombotin-2

1

4

High-throughput

0.541

High

673399

CUL3
Cullin-3

1

3

High-throughput

0.541

High

673402

CCNI
Cyclin-I

1

13

High-throughput

0.541

High

673404

IKBB
NF-kappa-B inhibitor beta

1

1

High-throughput

0.541

High

231283

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.518

High

365157

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

513831

DMD
Dystrophin

1

0

High-throughput

0.518

High

617729

NFYA
Nuclear transcription factor Y subunit alpha

1

0

High-throughput

0.518

High

673369

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.518

High

673370

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

673384

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

673394

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.518

High

673435

VAMP8
Vesicle-associated membrane protein 8

1

0

High-throughput

0.518

High

673440

FGF21
Fibroblast growth factor 21

1

0

High-throughput

0.518

High

673422

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

537815

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.513

High

176126

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

653492

CALR
Calreticulin

1

0

High-throughput

0.513

High

673437

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

673397

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

673430

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

394184

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

522807

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.480

High

127192

IPO5
Importin-5

1

2

High-throughput

0.479

High

216454

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.479

High

349146

RASH
GTPase HRas

1

1

Small-scale

0.479

High

590131

CCNA2
Cyclin-A2

1

8

High-throughput

0.479

High

673366

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

673367

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

673372

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

673375

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

673376

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

673377

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.479

High

673379

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.479

High

673391

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.479

High

673393

CDC20
Cell division cycle protein 20 homolog

1

2

High-throughput

0.479

High

673400

CUL4B
Cullin-4B

1

3

Small-scale

0.479

High

673410

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

673417

DJC10
DnaJ homolog subfamily C member 10

1

2

High-throughput

0.479

High

673420

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

673421

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

673423

TP4A1
Protein tyrosine phosphatase type IVA 1

1

3

High-throughput

0.479

High

673439

WDR6
tRNA

1

9

High-throughput

0.479

High

673449

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

Small-scale

0.479

High

165633

SET1A
Histone-lysine N-methyltransferase SETD1A

1

0

Small-scale

0.458

High

166889

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.458

High

177210

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

209702

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

295945

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

673368

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

673378

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

673385

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

673403

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.458

High

673405

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

673407

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

673411

DCAF8
DDB1- and CUL4-associated factor 8

1

0

Small-scale

0.458

High

673413

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.458

High

673414

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

673418

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

673419

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

673427

A7L3B
Ataxin-7-like protein 3B

1

0

High-throughput

0.458

High

673434

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.458

High

673436

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

673441

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.458

High

673445

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

673447

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

Small-scale

0.458

High

673448

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

673416

CC28A
Coiled-coil domain-containing protein 28A

1

1

High-throughput

0.437

High

673424

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

High-throughput

0.437

High

673429

APLD1
Apolipoprotein L domain-containing protein 1

1

1

High-throughput

0.437

High

673443

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.437

High

488135

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.282

High

645891

IL3RA
Interleukin-3 receptor subunit alpha

1

0

High-throughput

0.282

High

327229

DLGP3
Disks large-associated protein 3

1

0

High-throughput

0.249

Low

673412

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low

484431

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024