Protein: MK10
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)

Gene: MK10, MAPK10
Organism: Homo sapiens
Interactions: 60
UniProt ID: P53779

Gene Ontology (top 5):
GO:0004705 - JUN kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853880

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

3

20

Small-scale

0.834

High

923376

MK10
Mitogen-activated protein kinase 10

3

16

Small-scale

0.827

High

853772

MK09
Mitogen-activated protein kinase 9

2

18

High-throughput

0.776

High

429575

JUN
Transcription factor Jun

9

20

Small-scale

0.758

High

923395

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

20

Small-scale

0.756

High

923391

DDI1
Protein DDI1 homolog 1

2

4

High-throughput

0.726

High

923402

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

20

Small-scale

0.679

High

923392

TCPW
T-complex protein 1 subunit zeta-2

3

18

High-throughput

0.667

High

703921

DUS1
Dual specificity protein phosphatase 1

1

20

Small-scale

0.665

High

923404

DUS10
Dual specificity protein phosphatase 10

1

20

Small-scale

0.665

High

374493

RASH
GTPase HRas

1

9

Small-scale

0.647

High

842945

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

15

Small-scale

0.647

High

857293

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

12

Small-scale

0.647

High

923397

DUS9
Dual specificity protein phosphatase 9

1

20

Small-scale

0.647

High

882420

ARRB1
Beta-arrestin-1

3

9

Small-scale

0.646

High

358650

LDHA
L-lactate dehydrogenase A chain

3

9

High-throughput

0.635

High

583507

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

20

Small-scale

0.635

High

214557

WDR62
WD repeat-containing protein 62

2

16

High-throughput

0.628

High

582725

EZRI
Ezrin

2

12

High-throughput

0.628

High

683810

MOES
Moesin

2

12

High-throughput

0.628

High

578430

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

923398

DUS16
Dual specificity protein phosphatase 16

1

20

Small-scale

0.618

High

923378

TCPB
T-complex protein 1 subunit beta

2

18

High-throughput

0.611

High

732493

ARRB2
Beta-arrestin-2

2

9

Small-scale

0.595

High

124281

HAX1
HCLS1-associated protein X-1

2

0

High-throughput

0.588

High

853635

MK08
Mitogen-activated protein kinase 8

1

18

High-throughput

0.575

High

842697

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

19

Small-scale

0.573

High

923380

TF65
Transcription factor p65

1

11

High-throughput

0.573

High

923400

HDAC9
Histone deacetylase 9

1

13

Small-scale

0.561

High

605065

JUND
Transcription factor JunD

1

20

Small-scale

0.550

High

622429

ELK1
ETS domain-containing protein Elk-1

1

20

Small-scale

0.550

High

923382

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

13

Small-scale

0.550

High

923389

ZN239
Zinc finger protein 239

1

0

Small-scale

0.546

High

176952

CE290
Centrosomal protein of 290 kDa

1

12

High-throughput

0.541

High

923381

UBE3A
Ubiquitin-protein ligase E3A

1

5

High-throughput

0.541

High

923393

CBP
CREB-binding protein

1

11

High-throughput

0.541

High

923401

KI26A
Kinesin-like protein KIF26A

1

4

High-throughput

0.541

High

552542

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.536

High

767408

RADI
Radixin

1

12

High-throughput

0.536

High

923379

MYT1
Myelin transcription factor 1

1

3

Small-scale

0.536

High

923390

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

2

High-throughput

0.536

High

923383

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.518

High

923386

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

721705

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.515

High

211766

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

239415

3BP5
SH3 domain-binding protein 5

1

2

Small-scale

0.501

High

421775

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

529407

TAU
Microtubule-associated protein tau

1

19

Small-scale

0.501

High

923384

KIF5A
Kinesin heavy chain isoform 5A

1

2

Small-scale

0.501

High

923385

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

12

Small-scale

0.501

High

923403

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

923394

PLIN2
Perilipin-2

1

0

High-throughput

0.486

High

923388

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.481

High

413464

P53
Cellular tumor antigen p53

1

11

Small-scale

0.479

High

608514

DDX5
Probable ATP-dependent RNA helicase DDX5

1

6

High-throughput

0.479

High

923377

CTBP2
C-terminal-binding protein 2

1

4

High-throughput

0.479

High

923387

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

923396

TCPH
T-complex protein 1 subunit eta

1

19

High-throughput

0.479

High

923399

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.426

High


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Last updated: 11Aug2025