Protein: CDN2B
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)

Gene: CDN2B, CDKN2B
Organism: Homo sapiens
Interactions: 79
UniProt ID: P42772

Gene Ontology (top 5):
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007179 - transforming growth factor beta receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549084

CDK4
Cyclin-dependent kinase 4

18

16

Small-scale

0.991

High

842907

CDK6
Cyclin-dependent kinase 6

12

16

Small-scale

0.986

High

842908

CDK17
Cyclin-dependent kinase 17

2

1

High-throughput

0.783

High

842900

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

15

High-throughput

0.768

High

842929

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.742

High

212712

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

14

High-throughput

0.698

High

842906

ISL1
Insulin gene enhancer protein ISL-1

1

3

High-throughput

0.698

High

842912

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.678

High

842901

MAGAB
Melanoma-associated antigen 11

3

9

High-throughput

0.667

High

842922

P5CR3
Pyrroline-5-carboxylate reductase 3

3

1

Small-scale

0.653

High

400437

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

13

High-throughput

0.647

High

410693

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

413356

P53
Cellular tumor antigen p53

1

10

High-throughput

0.647

High

593303

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.647

High

728090

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.647

High

842899

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

13

High-throughput

0.647

High

842902

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

19

High-throughput

0.647

High

842903

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

High-throughput

0.647

High

842919

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.647

High

842934

LATS2
Serine/threonine-protein kinase LATS2

1

11

High-throughput

0.647

High

703477

MK01
Mitogen-activated protein kinase 1

1

11

High-throughput

0.618

High

842905

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

15

High-throughput

0.618

High

666807

CCNC
Cyclin-C

2

6

High-throughput

0.606

High

842911

INCA1
Protein INCA1

2

3

High-throughput

0.606

High

842924

CNKR3
Connector enhancer of kinase suppressor of ras 3

2

3

High-throughput

0.606

High

842933

PICK1
PRKCA-binding protein

2

3

High-throughput

0.606

High

842679

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

16

High-throughput

0.595

High

842936

SPG21
Maspardin

2

0

High-throughput

0.580

High

842939

VATH
V-type proton ATPase subunit H

2

0

High-throughput

0.580

High

465446

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.579

High

622546

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

4

High-throughput

0.579

High

648451

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.579

High

710110

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.579

High

842913

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

20

High-throughput

0.579

High

842932

NIF3L
NIF3-like protein 1

1

2

High-throughput

0.573

High

179472

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.541

High

327562

ELP1
Elongator complex protein 1

1

0

High-throughput

0.518

High

842937

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

578415

BRAF
Serine/threonine-protein kinase B-raf

1

14

High-throughput

0.506

High

162920

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

179686

MDM4
Protein Mdm4

1

6

High-throughput

0.501

High

371395

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.501

High

421664

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

521239

ARAF
Serine/threonine-protein kinase A-Raf

1

13

High-throughput

0.501

High

591246

CD44
CD44 antigen

1

4

High-throughput

0.501

High

666959

CCNE1
G1/S-specific cyclin-E1

1

2

High-throughput

0.501

High

693264

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

6

High-throughput

0.501

High

718775

CCND2
G1/S-specific cyclin-D2

1

8

High-throughput

0.501

High

767121

MERL
Merlin

1

20

High-throughput

0.501

High

842914

GRM1
Metabotropic glutamate receptor 1

1

3

High-throughput

0.501

High

842917

BECN1
Beclin-1

1

3

High-throughput

0.501

High

842918

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

842921

HIF1A
Hypoxia-inducible factor 1-alpha

1

6

High-throughput

0.501

High

842926

TSC1
Hamartin

1

18

High-throughput

0.501

High

842927

KAT2A
Histone acetyltransferase KAT2A

1

12

High-throughput

0.501

High

842930

GLIS2
Zinc finger protein GLIS2

1

4

High-throughput

0.501

High

842935

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.501

High

842941

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.501

High

842931

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.494

High

216887

KLF4
Krueppel-like factor 4

1

5

Small-scale

0.479

High

219707

FOXO3
Forkhead box protein O3

1

7

Small-scale

0.479

High

683791

MOES
Moesin

1

18

High-throughput

0.479

High

823823

PBX1
Pre-B-cell leukemia transcription factor 1

1

4

Small-scale

0.479

High

842904

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.479

High

842910

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

842915

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.479

High

842920

CDC37
Hsp90 co-chaperone Cdc37

1

4

High-throughput

0.479

High

842923

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

8

Small-scale

0.479

High

842938

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

842916

KLF5
Krueppel-like factor 5

1

5

Small-scale

0.470

High

472020

MET
Hepatocyte growth factor receptor

1

15

High-throughput

0.457

High

571185

HGF
Hepatocyte growth factor

1

6

High-throughput

0.457

High

755464

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.457

High

842928

TTYH2
Protein tweety homolog 2

1

1

High-throughput

0.457

High

842940

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.457

High

842909

MDM2
E3 ubiquitin-protein ligase Mdm2

1

6

Small-scale

0.445

High

67360

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.316

High

842925

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025