HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 619
+	Hs
		937464 CDN2D_HUMAN (6-159): 4.02e-48: 155: 45.81		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		1049008 TANC2_HUMAN (17-164): 5.58e-27: 107: 22.50		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		295492 PSD10_HUMAN (1-110): 5.52e-30: 110: 24.32		TF65_HUMAN (2-576): 4.76e-158: 466: 37.89
+	Hs
		295454 PSD10_HUMAN (1-110): 5.52e-30: 110: 24.32		NFKB1_HUMAN (1-375): 2.01e-145: 447: 37.47
+	Hs
		842733 CDN2A_HUMAN (3-140): 5.52e-22: 88.2: 39.57		TF65_HUMAN (2-576): 4.76e-158: 466: 37.89
+	Hs
		1045484 ANKH1_HUMAN (74-166): 6.6e-18: 81.9: 27.66		TF65_HUMAN (2-576): 4.76e-158: 466: 37.89
+	Hs
		1045780 EHMT1_HUMAN (8-84): 3.38e-16: 76.8: 20.51		TF65_HUMAN (2-576): 4.76e-158: 466: 37.89
+	Mm
		681981 ANR42_MOUSE (12-158): 6.14e-14: 70.1: 31.79		NFKB1_MOUSE (1-414): 1.83e-152: 465: 33.56
+	Hs
		626281 ANKH1_HUMAN (74-166): 6.6e-18: 81.9: 27.66		NFKB1_HUMAN (1-375): 2.01e-145: 447: 37.47
+	Hs
		1030029 EHMT2_HUMAN (107-168): 8.69e-09: 55.3: 22.22		RELB_HUMAN (2-479): 1.53e-143: 430: 35.04