HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~V-set
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1732
+	Hs
		845876 MUC18_HUMAN (1-646): 2.82e-136: 414: 100.00		MRCKB_HUMAN (1-1731): 0: 1429: 60.38
+	Hs
		845821 MUC18_HUMAN (1-646): 2.82e-136: 414: 100.00		LATS2_HUMAN (65-376): 3.55e-75: 275: 41.23
+	Hs
		157693 PXDN_HUMAN (183-555): 5.63e-61: 222: 20.77		CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42
+	Hs
		287732 ROBO2_HUMAN (1-646): 5.46e-100: 335: 14.54		KS6A5_HUMAN (60-334): 2.61e-72: 261: 27.46
+	Hs
		270783 MUC18_HUMAN (1-646): 2.82e-136: 414: 100.00		ROCK2_HUMAN (349-1052): 2.87e-23: 110: 13.87
+	Hs
		845629 MUC18_HUMAN (1-646): 2.82e-136: 414: 100.00		ROCK1_HUMAN (372-1052): 2.32e-22: 107: 11.77
+	Hs
		156745 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		CTRO_HUMAN (4-1022): 3.08e-130: 453: 24.42
+	Hs
		1361942 TITIN_HUMAN (218-567): 1.7e-10: 66.7: 12.76		ST38L_HUMAN (10-417): 2.89e-126: 405: 38.06
+	Rn
		564893 NCAM1_RAT (11-644): 3.87e-83: 281: 15.63		ROCK1_RAT (368-1052): 3.54e-18: 93.8: 12.47