HitPredict

Interactor 1: VAMP7 (P51809)
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)
Gene: VAMP7

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 220 Hs			1 295
+	Dm
		1095560 Q7JYX5_DROME (1-218): 3.74e-85: 253: 52.29		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Zm
		31296 A0A1D6KH00_MAIZE (2-211): 1.02e-87: 273: 33.02		A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80
+	Hs
		263203 SC22B_HUMAN (23-206): 4.4e-59: 186: 22.16		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		180842 YKT6_HUMAN (23-179): 3.99e-55: 176: 23.42		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		850592 VAMP7_HUMAN (1-220): 3.87e-90: 266: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		115802 M9PGI6_DROME (24-204): 2.11e-53: 172: 26.23		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		1095592 Q9W3M8_DROME (5-179): 4.42e-51: 165: 21.02		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		1178116 Q7JYX5_DROME (1-218): 3.74e-85: 253: 52.29		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Sc
		696563 YKT6_YEAST (5-179): 3.71e-52: 168: 22.73		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Dm
		1178122 Q7JYX5_DROME (1-218): 3.74e-85: 253: 52.29		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Sc
		605825 SEC22_YEAST (37-206): 4.98e-49: 161: 20.93		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Dm
		577215 SYB_DROME (99-215): 1.35e-32: 116: 26.50		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		263338 SC22B_HUMAN (23-206): 4.4e-59: 186: 22.16		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Sc
		696608 NYV1_YEAST (36-208): 2.42e-36: 129: 20.21		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		180923 YKT6_HUMAN (23-179): 3.99e-55: 176: 23.42		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		115822 M9PGI6_DROME (24-204): 2.11e-53: 172: 26.23		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1353755 Q9W3M8_DROME (5-179): 4.42e-51: 165: 21.02		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		115828 M9PGI6_DROME (24-204): 2.11e-53: 172: 26.23		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1366632 Q9W3M8_DROME (5-179): 4.42e-51: 165: 21.02		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		577238 SYB_DROME (99-215): 1.35e-32: 116: 26.50		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49