HitPredict

Interactor 1: VPS4 (P52917)
Vacuolar protein sorting-associated protein 4 (DOA4-independent degradation protein 6) (Protein END13) (Vacuolar protein-targeting protein 10)
Gene: VPS4

Interactor 2: IST1 (P53843)
Vacuolar protein sorting-associated protein IST1 (Increased sodium tolerance protein 1)
Gene: IST1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	26515066, 16554755, 18032584, 18032582
Identification Methods	pull down, affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005768 - endosome GO:0015031 - protein transport GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 437 Sc			1 298
+	Hs
		867078 VPS4A_HUMAN (3-435): 7.08e-117: 350: 58.73		IST1_HUMAN (11-204): 5.78e-62: 201: 32.14
+	Dm
		116124 Q9Y162_DROME (1-436): 3.05e-114: 343: 57.43		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Ce
		105539 Q9BL83_CAEEL (3-436): 1.04e-112: 339: 56.34		G5ECX8_CAEEL (9-195): 1.17e-59: 198: 31.25
+	Ce
		106470 Q9BL83_CAEEL (3-436): 1.04e-112: 339: 56.34		G5EDV6_CAEEL (9-195): 8.33e-60: 198: 31.25
+	Dm
		1373368 Q9Y162_DROME (1-436): 3.05e-114: 343: 57.43		Q9VRY6_DROME (7-197): 1.26e-57: 192: 29.74
+	Hs
		867072 SPAST_HUMAN (112-367): 1.5e-66: 225: 46.62		IST1_HUMAN (11-204): 5.78e-62: 201: 32.14
+	Dm
		116100 SPAST_DROME (113-433): 3.99e-60: 210: 40.25		M9PHL4_DROME (7-197): 4.03e-59: 195: 29.74
+	Dm
		1211024 SPAST_DROME (113-433): 3.99e-60: 210: 40.25		Q9VRY6_DROME (7-197): 1.26e-57: 192: 29.74