HitPredict

Interactor 1: JAG1 (P78504)
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Gene: JAG1

Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 11006133, 22487239
Identification Methods pull down, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DSL~EGF_CA, EGF~EGF, EGF~EGF_CA, EGF~hEGF, DL-JAG_EGF-like~EGF, EGF_CA~hEGF, EGF_CA~MNNL, MNNL~hEGF
Common GO terms GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007219 - Notch signaling pathway
GO:0045665 - negative regulation of neuron differentiation
and 1 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1218
Hs

1 2321
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Service provided by Combinatics, Japan

Last updated: 11Aug2025