HitPredict

Interactor 1: ARP3 (P47117)
Actin-related protein 3 (Actin-like protein ARP3) (Actin-like protein 3)
Gene: ARP3

Interactor 2: LAS17 (Q12446)
Proline-rich protein LAS17
Gene: LAS17

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	10322115, 27325766, 11533442, 29386393, 37968396, 38367669, 21035341
Identification Methods	coimmunoprecipitation, pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~WH2
Common GO terms	GO:0003779 - actin binding GO:0030479 - actin cortical patch GO:0045010 - actin nucleation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 449 Sc			1 633
+	Sp
		205821 ARP3_SCHPO (1-446): 0: 606: 68.01		WSP1_SCHPO (4-407): 1.6e-25: 113: 23.27
+	Sc
		948703 ACT_YEAST (1-442): 0: 513: 32.58		LAS17_YEAST (1-633): 1.21e-56: 204: 100.00
+	Hs
		133652 ACTB_HUMAN (1-444): 0: 521: 32.44		WASL_HUMAN (3-157): 3.05e-33: 135: 27.74
+	Hs
		133657 ACTG_HUMAN (3-444): 0: 521: 32.36		WASL_HUMAN (3-157): 3.05e-33: 135: 27.74
+	Hs
		133658 ACTC_HUMAN (2-444): 0: 515: 32.29		WASL_HUMAN (3-157): 3.05e-33: 135: 27.74
+	Hs
		842632 ARP3_HUMAN (7-449): 6.37e-172: 490: 58.35		WASP_HUMAN (3-401): 2.42e-33: 136: 18.75
+	Hs
		133654 ARP3_HUMAN (7-449): 6.37e-172: 490: 58.35		WASL_HUMAN (3-157): 3.05e-33: 135: 27.74
+	Hs
		590266 ACTA_HUMAN (2-444): 0: 512: 32.51		MUC1_HUMAN (112-582): 8.49e-23: 106: 10.04
+	Bt
		958073 ARP3_BOVIN (7-449): 6.37e-172: 490: 58.35		WASL_BOVIN (3-157): 1.97e-29: 124: 27.74
+	Hs
		215916 ACTC_HUMAN (2-444): 0: 515: 32.29		SYNJ1_HUMAN (87-451): 5.81e-10: 64.8: 10.68
+	Hs
		958138 ARP3_HUMAN (7-449): 6.37e-172: 490: 58.35		MICA3_HUMAN (111-632): 5.95e-10: 64.8: 11.36
+	Sp
		205820 ACT_SCHPO (8-440): 3.35e-80: 254: 34.93		WSP1_SCHPO (4-407): 1.6e-25: 113: 23.27