Protein: WASP
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)

Gene: WASP, WAS
Organism: Homo sapiens
Interactions: 105
UniProt ID: P42768

Gene Ontology (top 5):
GO:0002625 - regulation of T cell antigen processing and presentation
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005884 - actin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

842631

CDC42
Cell division control protein 42 homolog

16

20

Small-scale

0.986

High

219547

WIPF1
WAS/WASL-interacting protein family member 1

12

14

Small-scale

0.983

High

842619

WASP
Actin nucleation-promoting factor WAS

3

16

Small-scale

0.847

High

842633

ARP2
Actin-related protein 2

3

14

Small-scale

0.827

High

842658

WIPF2
WAS/WASL-interacting protein family member 2

2

6

Small-scale

0.757

High

842665

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

Small-scale

0.757

High

440429

FYN
Tyrosine-protein kinase Fyn

5

20

Small-scale

0.724

High

593936

NCK1
SH2/SH3 adapter protein NCK1

4

20

Small-scale

0.699

High

842642

BTK
Tyrosine-protein kinase BTK

4

20

Small-scale

0.696

High

486667

FGR
Tyrosine-protein kinase Fgr

3

20

Small-scale

0.670

High

842635

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.667

High

220747

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

3

20

Small-scale

0.664

High

179471

ARPC3
Actin-related protein 2/3 complex subunit 3

3

5

Small-scale

0.661

High

619004

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

2

Small-scale

0.651

High

842624

VASP
Vasodilator-stimulated phosphoprotein

1

10

Small-scale

0.647

High

842636

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

842638

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.647

High

473380

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.639

High

842653

CIP4
Cdc42-interacting protein 4

2

20

Small-scale

0.633

High

842666

ITSN2
Intersectin-2

2

20

Small-scale

0.633

High

842674

SNX9
Sorting nexin-9

2

20

Small-scale

0.631

High

222028

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.631

High

557159

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.629

High

842643

ACK1
Activated CDC42 kinase 1

2

20

Small-scale

0.629

High

699632

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

4

Small-scale

0.624

High

842623

RBP2
E3 SUMO-protein ligase RanBP2

2

3

Small-scale

0.624

High

580913

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

Small-scale

0.618

High

601203

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

Small-scale

0.618

High

842630

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

Small-scale

0.618

High

842634

RAN
GTP-binding nuclear protein Ran

1

6

Small-scale

0.618

High

842644

ITK
Tyrosine-protein kinase ITK/TSK

2

20

Small-scale

0.613

High

439985

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.611

High

842628

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

20

High-throughput

0.606

High

179158

ARC1B
Actin-related protein 2/3 complex subunit 1B

2

10

Small-scale

0.595

High

842654

ITSN1
Intersectin-1

2

20

Small-scale

0.584

High

842663

FNBP1
Formin-binding protein 1

2

20

Small-scale

0.584

High

842664

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

20

Small-scale

0.584

High

842667

ABI3
ABI gene family member 3

2

20

High-throughput

0.584

High

842632

ARP3
Actin-related protein 3

1

15

Small-scale

0.575

High

640370

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

Small-scale

0.573

High

320221

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

High-throughput

0.573

High

842661

APBP2
Amyloid protein-binding protein 2

1

2

High-throughput

0.573

High

842641

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

10

Small-scale

0.571

High

842621

CRKL
Crk-like protein

1

20

Small-scale

0.561

High

258370

GAS7
Growth arrest-specific protein 7

2

20

Small-scale

0.555

High

842629

ARPC4
Actin-related protein 2/3 complex subunit 4

1

4

Small-scale

0.536

High

286434

WBP4
WW domain-binding protein 4

1

8

High-throughput

0.527

High

840865

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.527

High

541876

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.513

High

841638

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

159552

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

8

High-throughput

0.508

High

127015

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

163718

TCRG1
Transcription elongation regulator 1

1

16

High-throughput

0.501

High

179316

ARPC2
Actin-related protein 2/3 complex subunit 2

1

6

Small-scale

0.501

High

588115

RFA2
Replication protein A 32 kDa subunit

1

4

Small-scale

0.501

High

694833

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

Small-scale

0.501

High

767610

RFA3
Replication protein A 14 kDa subunit

1

3

Small-scale

0.501

High

842670

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

20

Small-scale

0.501

High

542368

TOP2A
DNA topoisomerase 2-alpha

1

3

Small-scale

0.484

High

842639

TOP2B
DNA topoisomerase 2-beta

1

4

Small-scale

0.484

High

220440

RGS14
Regulator of G-protein signaling 14

1

1

High-throughput

0.481

High

319203

FCSD2
F-BAR and double SH3 domains protein 2

1

20

High-throughput

0.481

High

842662

CBP
CREB-binding protein

1

11

Small-scale

0.481

High

138643

IMA4
Importin subunit alpha-4

1

5

Small-scale

0.479

High

142494

IMA3
Importin subunit alpha-3

1

5

Small-scale

0.479

High

172546

XPO1
Exportin-1

1

7

Small-scale

0.479

High

176035

KDM6B
Lysine-specific demethylase 6B

1

8

Small-scale

0.479

High

178078

FYB1
FYN-binding protein 1

1

5

Small-scale

0.479

High

224648

ACTN4
Alpha-actinin-4

1

5

Small-scale

0.479

High

269525

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

5

Small-scale

0.479

High

273410

KDM4A
Lysine-specific demethylase 4A

1

1

Small-scale

0.479

High

362930

EGFR
Epidermal growth factor receptor

1

11

Small-scale

0.479

High

571659

HCLS1
Hematopoietic lineage cell-specific protein

1

20

Small-scale

0.479

High

651207

CBL
E3 ubiquitin-protein ligase CBL

1

7

Small-scale

0.479

High

842625

IMA1
Importin subunit alpha-1

1

5

Small-scale

0.479

High

842626

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

Small-scale

0.479

High

842627

XPO2
Exportin-2

1

7

Small-scale

0.479

High

842637

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.479

High

842640

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

842646

LCP2
Lymphocyte cytosolic protein 2

1

6

Small-scale

0.479

High

842647

CBLB
E3 ubiquitin-protein ligase CBL-B

1

7

Small-scale

0.479

High

842648

CUL4B
Cullin-4B

1

7

High-throughput

0.479

High

842649

SRC8
Src substrate cortactin

1

20

Small-scale

0.479

High

842651

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

842652

RBBP5
Retinoblastoma-binding protein 5

1

8

Small-scale

0.479

High

842656

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

842657

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

2

Small-scale

0.479

High

842659

SNX33
Sorting nexin-33

1

20

Small-scale

0.479

High

842671

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

20

Small-scale

0.479

High

842672

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

20

Small-scale

0.479

High

842620

RAGP1
Ran GTPase-activating protein 1

1

0

Small-scale

0.458

High

842622

GLIP1
Glioma pathogenesis-related protein 1

1

0

Small-scale

0.458

High

842668

SAE1
SUMO-activating enzyme subunit 1

1

0

Small-scale

0.458

High

280535

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.457

High

842660

ROBO4
Roundabout homolog 4

1

6

Small-scale

0.457

High

471734

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

6

High-throughput

0.445

High

658814

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

9

High-throughput

0.445

High

658999

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

6

High-throughput

0.445

High

659077

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

8

High-throughput

0.445

High

842645

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

9

High-throughput

0.445

High

842655

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

6

High-throughput

0.445

High

842673

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

11

High-throughput

0.445

High

842650

RBM39
RNA-binding protein 39

1

6

High-throughput

0.437

High

842669

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025