HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	27114451, 34761751, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin, UCH_C~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070628 - proteasome binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 329
+	Rn
		1117322 RD23B_RAT (1-409): 1.14e-120: 358: 87.23		Q5HZY3_RAT (1-315): 9.4e-171: 478: 97.46
+	Hs
		872237 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		1357351 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Mm
		477056 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UCHL5_MOUSE (1-329): 7.44e-176: 491: 96.96
+	Dm
		547969 RS27A_DROME (1-75): 3.83e-15: 74.2: 32.00		Q9XZ61_DROME (1-328): 2.79e-148: 421: 59.76
+	Hs
		548135 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Hs
		872291 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Dm
		547926 RS27A_DROME (1-75): 3.83e-15: 74.2: 32.00		CALYP_DROME (1-315): 2.37e-121: 359: 33.43
+	Mm
		477030 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UCHL3_MOUSE (4-226): 2.22e-84: 256: 26.61
+	Hs
		474910 UBB_HUMAN (1-79): 1.99e-32: 123: 30.38		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Hs
		548107 Q5U5U6_HUMAN (1-79): 1.99e-32: 123: 30.38		UCHL3_HUMAN (4-226): 7.17e-85: 257: 26.18
+	Mm
		476730 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UCHL4_MOUSE (4-226): 6.61e-81: 247: 26.27
+	Mm
		477047 UBC_MOUSE (1-118): 1.78e-32: 131: 21.67		UCHL1_MOUSE (10-226): 1.44e-72: 225: 22.67
+	Hs
		456474 UBB_HUMAN (1-79): 1.99e-32: 123: 30.38		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Hs
		456536 RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67		UCHL1_HUMAN (10-226): 1.03e-74: 231: 22.22
+	Sc
		477613 RL40A_YEAST (1-84): 4.44e-14: 70.4: 28.57		UBL1_YEAST (1-226): 3.54e-61: 196: 24.58
+	Hs
		924096 RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29