HitPredict

Interactor 1: LHX1 (P48742)
LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1)
Gene: LHX1

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain, LIM~LIM
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000987 - cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 359
+	Hs
		961493 LHX3_HUMAN (1-377): 7.9e-56: 190: 33.42		ISL1_HUMAN (14-358): 2.62e-86: 266: 73.91
+	Hs
		961485 LMX1A_HUMAN (2-347): 1.01e-55: 189: 29.26		ISL1_HUMAN (14-358): 2.62e-86: 266: 73.91
+	Hs
		961487 LHX4_HUMAN (1-398): 1.6e-54: 187: 31.97		ISL1_HUMAN (14-358): 2.62e-86: 266: 73.91
+	Hs
		1382434 LHX3_HUMAN (1-377): 7.9e-56: 190: 33.42		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Mm
		923326 LHX4_MOUSE (1-398): 5.06e-55: 188: 32.21		ISL2_MOUSE (1-359): 1.35e-84: 262: 98.61
+	Hs
		1379927 LHX4_HUMAN (1-398): 1.6e-54: 187: 31.97		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Mm
		895872 LHX3_MOUSE (1-374): 7.33e-53: 183: 34.21		ISL1_MOUSE (14-358): 2.62e-86: 266: 73.91
+	Dm
		120439 M9PD53_DROME (1-376): 6.1e-51: 181: 31.10		P92031_DROME (6-345): 2.26e-62: 209: 51.61
+	Dm
		1477947 Q9VJ00_DROME (1-376): 1.72e-50: 179: 31.10		Q9VJ37_DROME (6-345): 1.08e-62: 210: 52.15
+	Hs
		965497 LHX4_HUMAN (1-398): 1.6e-54: 187: 31.97		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Ce
		110437 LIN11_CAEEL (2-320): 1.19e-53: 185: 42.01		LIM7_CAEEL (8-355): 7.54e-51: 177: 31.25
+	Hs
		877572 LHX1_HUMAN (1-406): 1.75e-90: 280: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		1347385 LHX5_HUMAN (1-406): 1.72e-75: 241: 73.46		LMO3_HUMAN (27-148): 1.54e-26: 104: 40.16
+	Hs
		1347340 LHX4_HUMAN (1-398): 1.6e-54: 187: 31.97		LMO3_HUMAN (27-148): 1.54e-26: 104: 40.16
+	Hs
		1379961 LHX3_HUMAN (1-377): 7.9e-56: 190: 33.42		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		1352080 LHX3_HUMAN (1-377): 7.9e-56: 190: 33.42		LMX1A_HUMAN (7-83): 4.74e-17: 83.5: 20.78
+	Hs
		1352078 LMX1A_HUMAN (2-347): 1.01e-55: 189: 29.26		LMX1A_HUMAN (7-83): 4.74e-17: 83.5: 20.78