HitPredict

Interactor 1: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Interactor 2: MED1 (Q15648)
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
Gene: MED1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.765

The method score is based on:

Property Details
Experiments 28514442, 24981860, 33961781, 15989967, 20098423, 23322298, 26186194, 26496610, 29568061, 10198638, 11867769, 32707033, 10024883, 10882111, 23602568, unassigned1655, 18418385
Identification Methods affinity chromatography technology, proximity labelling technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification, ion exchange chromatography
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0016592 - mediator complex
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 464
Hs

1 1581
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Last updated: 11Aug2025