HitPredict

Interactor 1: KDM4A (O75164)
Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)
Gene: KDM4A

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.568

Property	Details
Experiments	17567753
Identification Methods	demethylase assay, x-ray crystallography, surface plasmon resonance
Interaction Type	demethylation reaction, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1064 Hs			1 136
+	Hs
		273420 KDM4A_HUMAN (1-1064): 0: 1133: 100.00		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		273422 KDM4A_HUMAN (1-1064): 0: 1133: 100.00		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		998802 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		1017205 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		1258941 KDM4C_HUMAN (1-1064): 0: 1055: 53.47		H32_HUMAN (1-136): 6e-61: 185: 96.32
+	Hs
		322652 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		322654 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		322666 KDM4B_HUMAN (1-1064): 0: 1049: 49.95		H3C_HUMAN (1-136): 9.7e-59: 179: 90.44
+	Dm
		381721 KDM4B_DROME (8-438): 2.82e-157: 480: 51.59		H3_DROME (1-136): 6e-61: 185: 96.32
+	Dm
		381718 KDM4A_DROME (5-465): 4.39e-155: 471: 48.33		H3_DROME (1-136): 6e-61: 185: 96.32
+	Sc
		815785 RPH1_YEAST (1-731): 5.08e-148: 463: 22.03		H3_YEAST (1-136): 8.07e-56: 172: 86.03
+	Sc
		866138 JHD2_YEAST (25-449): 7.04e-107: 352: 22.03		H3_YEAST (1-136): 8.07e-56: 172: 86.03
+	Hs
		936644 BRPF1_HUMAN (432-926): 5.28e-85: 301: 18.70		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		936646 BRPF1_HUMAN (432-926): 5.28e-85: 301: 18.70		H33_HUMAN (1-136): 1.86e-61: 186: 93.38
+	Hs
		936656 BRPF1_HUMAN (432-926): 5.28e-85: 301: 18.70		H32_HUMAN (1-136): 6e-61: 185: 96.32
+	Sp
		489137 LID2_SCHPO (34-475): 3.19e-85: 304: 14.96		H31_SCHPO (1-136): 2.84e-59: 181: 88.97
+	Sp
		531215 LID2_SCHPO (34-475): 3.19e-85: 304: 14.96		H33_SCHPO (1-136): 5.91e-58: 177: 88.24
+	Sc
		963692 GIS1_YEAST (4-312): 1.59e-87: 303: 27.94		H3_YEAST (1-136): 8.07e-56: 172: 86.03
+	Hs
		342152 BRD1_HUMAN (484-925): 3.8e-79: 282: 19.65		H31_HUMAN (1-136): 3.36e-62: 188: 97.06
+	Hs
		883492 BRPF1_HUMAN (432-926): 5.28e-85: 301: 18.70		CENPA_HUMAN (9-133): 3.55e-44: 142: 49.24