HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 418
+	Hs
		431704 RIPK4_HUMAN (1-832): 0: 726: 100.00		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		538174 RIPK4_HUMAN (1-832): 0: 726: 100.00		ENPL_HUMAN (96-407): 1.36e-36: 144: 26.90
+	Hs
		432263 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		432186 Q96T11_HUMAN (1-832): 0: 691: 90.51		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438529 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		538399 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ENPL_HUMAN (96-407): 1.36e-36: 144: 26.90
+	Hs
		1123530 ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47		HS904_HUMAN (1-418): 0: 547: 100.00
+	Hs
		431682 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438082 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		201744 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		432073 ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438365 ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		438117 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		432396 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		431824 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41
+	Hs
		438651 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		438144 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		HS90B_HUMAN (96-256): 4.57e-41: 156: 51.85
+	Hs
		1123425 ANKK1_HUMAN (342-643): 1.15e-46: 180: 19.47		H90B4_HUMAN (112-275): 1.78e-26: 112: 42.42