Protein: AMPL
Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I)

Gene: AMPL, APE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 95
UniProt ID: P14904

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0005737 - cytoplasm
GO:0006508 - proteolysis
GO:0008270 - zinc ion binding
GO:0032258 - cytoplasm to vacuole targeting by the Cvt pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

541509

AMPL
Vacuolar aminopeptidase 1

8

4

Small-scale

0.972

High

541546

DNPEP
Aspartyl aminopeptidase 4

2

4

High-throughput

0.775

High

541541

ATG19
Autophagy-related protein 19

17

2

Small-scale

0.765

High

541544

ATG8
Autophagy-related protein 8

4

2

Small-scale

0.680

High

541522

MAN1
Alpha-mannosidase

3

0

High-throughput

0.636

High

541584

ATG11
Autophagy-related protein 11

3

0

Small-scale

0.626

High

541578

ADY3
Accumulates dyads protein 3

2

0

High-throughput

0.594

High

541562

ATG1
Serine/threonine-protein kinase ATG1

2

0

Small-scale

0.569

High

541581

ATG9
Autophagy-related protein 9

2

0

Small-scale

0.569

High

541528

BMH1
Protein BMH1

2

0

High-throughput

0.569

High

541535

TFB1
General transcription and DNA repair factor IIH subunit TFB1

2

1

High-throughput

0.566

High

541510

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.559

High

541569

IMA1
Importin subunit alpha

1

1

High-throughput

0.541

High

510124

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

541517

PHO80
PHO85 cyclin PHO80

1

1

High-throughput

0.536

High

541553

PCL6
PHO85 cyclin-6

1

1

High-throughput

0.536

High

540517

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

541514

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

0

High-throughput

0.513

High

541527

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

541529

XPO1
Exportin-1

1

0

High-throughput

0.513

High

541548

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.513

High

541552

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.513

High

541561

MRK1
Serine/threonine-protein kinase MRK1

1

0

High-throughput

0.513

High

541579

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.513

High

541564

AF9
Protein AF-9 homolog

1

1

High-throughput

0.508

High

541582

ATG34
Autophagy-related protein 34

1

2

Small-scale

0.501

High

505140

PYC1
Pyruvate carboxylase 1

1

1

High-throughput

0.500

High

541530

PYC2
Pyruvate carboxylase 2

1

1

High-throughput

0.500

High

541547

TEM1
Protein TEM1

1

3

High-throughput

0.494

High

541549

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.486

High

541556

SEC24
Protein transport protein SEC24

1

0

High-throughput

0.486

High

541572

TR130
Trafficking protein particle complex II-specific subunit 130

1

0

High-throughput

0.486

High

342639

ENO1
Enolase 1

1

0

High-throughput

0.479

High

404294

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

410884

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

537339

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

541511

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

541551

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

541571

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.479

High

541538

YPT7
Ypt/Rab-type GTPase YPT7

1

2

High-throughput

0.479

High

541585

YPT6
GTP-binding protein YPT6

1

2

High-throughput

0.479

High

541532

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.464

High

536277

CPYI
Carboxypeptidase Y inhibitor

1

0

Small-scale

0.458

High

541518

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

541521

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

541531

SP110
Spindle pole body component 110

1

0

High-throughput

0.458

High

541537

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

541550

SS120
Protein SSP120

1

0

High-throughput

0.458

High

541555

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

541568

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

541573

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.458

High

541580

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

541583

NAA25
N-terminal acetyltransferase B complex subunit MDM20

1

0

High-throughput

0.458

High

343517

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

378269

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

541513

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.457

High

490208

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

541534

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

541554

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

541570

TRS31
Trafficking protein particle complex subunit 31

1

1

High-throughput

0.437

High

541512

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

541557

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

541565

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.426

High

541524

MXR2
Peptide methionine sulfoxide reductase 2

2

0

Small-scale

0.327

High

355325

H2B1
Histone H2B.1

1

0

High-throughput

0.279

Low

514525

BIK1
Nuclear fusion protein BIK1

1

0

High-throughput

0.279

Low

541520

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.279

Low

541540

CLG1
PHO85 cyclin CLG1

1

0

High-throughput

0.279

Low

541558

MIL1
Probable lipase MIL1

1

0

High-throughput

0.279

Low

541566

H3
Histone H3

1

0

High-throughput

0.279

Low

541525

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.265

Low

541543

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.265

Low

541567

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.265

Low

541577

SWC7
SWR1-complex protein 7

1

0

High-throughput

0.265

Low

541576

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.261

Low

397570

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

410743

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

541515

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

541519

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

420042

TYSY
Thymidylate synthase

1

0

High-throughput

0.249

Low

520305

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

Small-scale

0.249

Low

541523

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

541526

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

541533

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low

541536

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

541539

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.249

Low

541542

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

541545

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

541559

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

541560

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

541563

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.249

Low

541574

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

541575

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

541516

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024