HitPredict

Interactor 1: SYJ2B (P57105)
Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25)
Gene: SYNJ2BP

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016323 - basolateral plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 145 Hs			1 4544
+	Mm
		1265297 SYJ2B_MOUSE (1-145): 6.21e-45: 145: 91.03		LRP1_MOUSE (24-4544): 0: 3516: 98.08
+	Hs
		942331 DLG4_HUMAN (3-142): 4.24e-27: 106: 31.94		LRP1_HUMAN (24-4544): 0: 3520: 100.00
+	Mm
		1143471 DLG4_MOUSE (3-142): 4.36e-27: 106: 31.94		LRP1_MOUSE (24-4544): 0: 3516: 98.08
+	Hs
		883907 SYJ2B_HUMAN (1-145): 1.52e-45: 147: 100.00		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		883911 SYJ2B_HUMAN (1-145): 1.52e-45: 147: 100.00		LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54
+	Mm
		57561 SYJ2B_MOUSE (1-145): 6.21e-45: 145: 91.03		LRP2_MOUSE (3242-3468): 6.42e-09: 64.9: 19.67
+	Mm
		1267815 SNTG2_MOUSE (3-144): 2.89e-31: 118: 23.38		LRP1B_MOUSE (2-282): 3.55e-13: 79.1: 18.58
+	Dm
		113371 M9NFI9_DROME (14-110): 8.14e-30: 115: 32.65		Q9VBN2_DROME (769-1033): 4.21e-14: 81.8: 17.88
+	Dm
		113773 M9NFI9_DROME (14-110): 8.14e-30: 115: 32.65		Q9W4Y3_DROME (27-104): 6.3e-10: 68.6: 43.59
+	Hs
		942324 DLG4_HUMAN (3-142): 4.24e-27: 106: 31.94		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		957608 DLG2_HUMAN (6-142): 7.86e-27: 106: 29.79		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50
+	Hs
		942339 DLG4_HUMAN (3-142): 4.24e-27: 106: 31.94		LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54
+	Mm
		69882 DLG4_MOUSE (3-142): 4.36e-27: 106: 31.94		B1AXJ3_MOUSE (4296-4529): 1.43e-09: 66.8: 9.89
+	Mm
		57225 A2AKD7_MOUSE (7-141): 5.86e-28: 108: 25.00		NID1_MOUSE (2934-3029): 8.26e-09: 64.5: 30.39
+	Mm
		1143476 DLG4_MOUSE (3-142): 4.36e-27: 106: 31.94		LRP8_MOUSE (15-263): 2.82e-09: 66: 18.61
+	Mm
		57555 DLG4_MOUSE (3-142): 4.36e-27: 106: 31.94		LRP2_MOUSE (3242-3468): 6.42e-09: 64.9: 19.67
+	Hs
		957631 DLG3_HUMAN (1-121): 2.05e-23: 96.6: 38.84		LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50