HitPredict

Interactor 1: ACT (P60010)
Actin (EC 3.6.4.-)
Gene: ACT1

Interactor 2: ARP8 (Q12386)
Actin-like protein ARP8
Gene: ARP8

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	30120252, 30177756, 15607974, 37968396, 21499228
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006281 - DNA repair GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription and 1 others more... GO:0031011 - Ino80 complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 375 Sc			1 881
+	Hs
		892037 ACTB_HUMAN (1-375): 0: 601: 88.80		ARP8_HUMAN (264-881): 0: 559: 24.37
+	Hs
		891818 ACTBL_HUMAN (2-375): 0: 687: 83.42		ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		915402 ACTBL_HUMAN (2-375): 0: 687: 83.42		ACTA_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Hs
		932195 ACTBL_HUMAN (2-375): 0: 687: 83.42		ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Hs
		60342 ACTBL_HUMAN (2-375): 0: 687: 83.42		POTEF_HUMAN (93-265): 2.71e-44: 175: 16.58
+	Gg
		891646 ACTB_CHICK (1-375): 0: 601: 88.80		ACTB_CHICK (730-877): 6.7e-56: 199: 15.66
+	Hs
		891648 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		891675 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		929883 Q1KLZ0_HUMAN (1-375): 0: 601: 88.80		ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66
+	Hs
		891666 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTA_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Hs
		891680 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15
+	Hs
		891681 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTS_HUMAN (706-877): 1.69e-54: 195: 14.63
+	Hs
		891676 ACTB_HUMAN (1-375): 0: 601: 88.80		ACTH_HUMAN (706-877): 6.13e-54: 193: 14.15
+	Hs
		474804 ACTB_HUMAN (1-375): 0: 601: 88.80		POTEI_HUMAN (93-265): 6.88e-45: 177: 17.11
+	Hs
		474872 ACTB_HUMAN (1-375): 0: 601: 88.80		POTEJ_HUMAN (93-265): 1.94e-44: 175: 17.11
+	Hs
		891845 ACTB_HUMAN (1-375): 0: 601: 88.80		POTEE_HUMAN (93-265): 1.35e-42: 170: 16.58
+	Hs
		891654 ACTB_HUMAN (1-375): 0: 601: 88.80		ARP2_HUMAN (405-619): 8.71e-18: 88.7: 21.88
+	Hs
		896866 ACTG_HUMAN (1-375): 0: 600: 89.07		ARP2_HUMAN (405-619): 8.71e-18: 88.7: 21.88