Protein: PSB4
Proteasome subunit beta type-4 (Macropain subunit C11) (Multicatalytic endopeptidase complex subunit C11) (Proteasome component C11) (Proteinase YSCE subunit 11)

Gene: PSB4, PRE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: P22141

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645176

PSA4
Proteasome subunit alpha type-4

20

20

Small-scale

0.988

High

636533

PSA7
Probable proteasome subunit alpha type-7

19

20

Small-scale

0.987

High

645137

PSB5
Proteasome subunit beta type-5

18

20

Small-scale

0.985

High

645148

PRS7
26S proteasome regulatory subunit 7 homolog

16

20

Small-scale

0.982

High

645124

PSA3
Proteasome subunit alpha type-3

15

20

Small-scale

0.982

High

645125

PSA2
Proteasome subunit alpha type-2

15

20

Small-scale

0.982

High

645140

PSA5
Proteasome subunit alpha type-5

14

20

Small-scale

0.981

High

645175

PSA6
Proteasome subunit alpha type-6

14

20

Small-scale

0.981

High

645138

PSB7
Proteasome subunit beta type-7

14

20

Small-scale

0.980

High

636622

PSA1
Proteasome subunit alpha type-1

13

20

Small-scale

0.979

High

645128

PSB3
Proteasome subunit beta type-3

14

20

Small-scale

0.979

High

645163

PSB1
Proteasome subunit beta type-1

13

20

Small-scale

0.978

High

645126

PSB6
Proteasome subunit beta type-6

12

20

Small-scale

0.975

High

645217

RPN5
26S proteasome regulatory subunit RPN5

10

20

Small-scale

0.973

High

645127

PSB2
Proteasome subunit beta type-2

10

20

Small-scale

0.966

High

645200

PRS8
26S proteasome regulatory subunit 8 homolog

9

20

Small-scale

0.963

High

645157

UMP1
Proteasome maturation factor UMP1

8

3

Small-scale

0.958

High

645146

PRS6A
26S proteasome regulatory subunit 6A

6

20

Small-scale

0.935

High

645193

PRS10
26S proteasome subunit RPT4

5

20

Small-scale

0.906

High

645120

PSB4
Proteasome subunit beta type-4

5

20

Small-scale

0.902

High

645147

PRS6B
26S proteasome regulatory subunit 6B homolog

4

20

Small-scale

0.881

High

645177

PRS4
26S proteasome regulatory subunit 4 homolog

4

20

Small-scale

0.881

High

645218

RPN6
26S proteasome regulatory subunit RPN6

4

20

Small-scale

0.881

High

645180

BLM10
Proteasome activator BLM10

4

11

Small-scale

0.866

High

645206

POC1
Proteasome chaperone 1

6

3

Small-scale

0.836

High

645181

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

15

20

Small-scale

0.758

High

645131

CDC48
Cell division control protein 48

2

12

Small-scale

0.754

High

645171

RPN10
26S proteasome regulatory subunit RPN10

10

13

Small-scale

0.753

High

645141

RPN12
26S proteasome regulatory subunit RPN12

9

8

Small-scale

0.750

High

645214

RPN8
26S proteasome regulatory subunit RPN8

9

20

Small-scale

0.747

High

645151

POC2
Proteasome assembly chaperone 2

7

3

Small-scale

0.741

High

645167

RPN1
26S proteasome regulatory subunit RPN1

6

20

Small-scale

0.724

High

645173

RPN3
26S proteasome regulatory subunit RPN3

5

9

Small-scale

0.706

High

645145

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.699

High

150259

RPN13
26S proteasome regulatory subunit RPN13

4

2

Small-scale

0.683

High

645142

RPN2
26S proteasome regulatory subunit RPN2

4

20

Small-scale

0.683

High

645202

RPN9
26S proteasome regulatory subunit RPN9

4

13

Small-scale

0.683

High

645209

RPN7
26S proteasome regulatory subunit RPN7

4

20

Small-scale

0.683

High

523072

HSP71
Heat shock protein SSA1

4

14

Small-scale

0.676

High

645182

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

15

Small-scale

0.676

High

645130

FUB1
Silencing boundary-establishment protein FUB1

2

3

Small-scale

0.675

High

645188

PSD10
Probable 26S proteasome regulatory subunit p28

3

2

Small-scale

0.651

High

314841

SEM1
26S proteasome complex subunit SEM1

3

2

Small-scale

0.650

High

394241

EF1A
Elongation factor 1-alpha

3

1

Small-scale

0.646

High

645166

ECM29
Proteasome component ECM29

3

13

Small-scale

0.640

High

645203

PDS5
Sister chromatid cohesion protein PDS5

2

2

Small-scale

0.620

High

645213

POC3
Proteasome chaperone 3

1

1

Small-scale

0.618

High

645216

POC4
Proteasome chaperone 4

1

1

Small-scale

0.618

High

509399

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

Small-scale

0.584

High

525934

HSP72
Heat shock protein SSA2

2

14

Small-scale

0.584

High

578856

HSC82
ATP-dependent molecular chaperone HSC82

2

8

Small-scale

0.584

High

645186

DSK2
Ubiquitin domain-containing protein DSK2

2

20

Small-scale

0.584

High

585679

UBC4
Ubiquitin-conjugating enzyme E2 4

2

5

Small-scale

0.571

High

645174

SSB2
Ribosome-associated molecular chaperone SSB2

2

14

Small-scale

0.571

High

645165

YHJ3
Uncharacterized protein YHR033W

1

1

High-throughput

0.536

High

645194

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

645123

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

3

High-throughput

0.515

High

645134

CIN8
Kinesin-like protein CIN8

1

1

High-throughput

0.515

High

645191

TOS8
Homeobox protein TOS8

1

1

High-throughput

0.515

High

368589

PMG1
Phosphoglycerate mutase 1

1

2

High-throughput

0.500

High

626587

HSP60
Heat shock protein 60, mitochondrial

1

6

High-throughput

0.500

High

645159

HSM3
DNA mismatch repair protein HSM3

1

1

Small-scale

0.500

High

645192

RPN14
26S proteasome regulatory subunit RPN14

1

3

Small-scale

0.500

High

557664

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.493

High

645158

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

Small-scale

0.493

High

645164

SIC1
Protein SIC1

1

0

Small-scale

0.480

High

405029

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.479

High

531244

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

590530

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

367893

ENO2
Enolase 2

1

3

Small-scale

0.479

High

380970

H2B1
Histone H2B.1

1

1

Small-scale

0.479

High

401889

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

438520

UBC2
Ubiquitin-conjugating enzyme E2 2

1

8

Small-scale

0.479

High

531605

RL4A
Large ribosomal subunit protein uL4A

1

2

Small-scale

0.479

High

640542

UBC1
Ubiquitin-conjugating enzyme E2 1

1

7

Small-scale

0.479

High

645121

HSP74
Heat shock protein SSA4

1

13

Small-scale

0.479

High

645135

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

645136

BMH1
Protein BMH1

1

2

Small-scale

0.479

High

645139

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

645143

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

Small-scale

0.479

High

645144

HSP7F
Heat shock protein homolog SSE1

1

18

Small-scale

0.479

High

645149

BMH2
Protein BMH2

1

2

Small-scale

0.479

High

645150

EF1G2
Elongation factor 1-gamma 2

1

5

High-throughput

0.479

High

645153

GBLP
Small ribosomal subunit protein RACK1

1

5

Small-scale

0.479

High

645187

RL4B
Large ribosomal subunit protein uL4B

1

2

Small-scale

0.479

High

645190

HUL5
E3 ubiquitin-protein ligase HUL5

1

20

Small-scale

0.479

High

645196

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

645197

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.479

High

645198

CDC14
Tyrosine-protein phosphatase CDC14

1

5

High-throughput

0.479

High

645199

ACAC
Acetyl-CoA carboxylase

1

1

Small-scale

0.479

High

368222

TRP
Tryptophan synthase

1

0

Small-scale

0.458

High

432799

RL9A
Large ribosomal subunit protein uL6A

1

0

Small-scale

0.458

High

434831

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

453422

PYR1
Multifunctional protein URA2

1

0

Small-scale

0.458

High

513630

RL2A
Large ribosomal subunit protein uL2A

1

0

Small-scale

0.458

High

514228

RL12B
Large ribosomal subunit protein uL11B

1

0

Small-scale

0.458

High

645122

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

645133

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.458

High

645156

INCE
Inner centromere protein SLI15

1

0

Small-scale

0.458

High

645160

PAF1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.458

High

645161

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.458

High

645169

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

645178

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

645189

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.458

High

645195

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

645205

LTN1
E3 ubiquitin-protein ligase listerin

1

0

Small-scale

0.458

High

645211

UBX5
UBX domain-containing protein 5

1

0

Small-scale

0.458

High

645215

YL054
Uncharacterized transcriptional regulatory protein YLL054C

1

0

Small-scale

0.458

High

645219

RL13A
Large ribosomal subunit protein eL13A

1

0

Small-scale

0.458

High

645185

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.457

High

364332

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.445

High

597383

EF3A
Elongation factor 3A

1

1

High-throughput

0.437

High

645132

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

645152

GLYC
Serine hydroxymethyltransferase, cytosolic

1

3

Small-scale

0.437

High

645154

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

645155

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.437

High

645172

PAC2
Protein PAC2

1

5

Small-scale

0.437

High

645179

MPG1
Mannose-1-phosphate guanyltransferase

2

0

Small-scale

0.310

High

645204

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

645183

YJN2
Uncharacterized protein YJL132W

1

0

High-throughput

0.269

Low

645208

COQ11
MIOREX complex component 2

1

0

High-throughput

0.269

Low

645212

ACK1
Activator of C kinase protein 1

1

0

High-throughput

0.269

Low

596795

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

0

Small-scale

0.249

Low

645129

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

Small-scale

0.249

Low

645162

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

Small-scale

0.249

Low

645168

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

645170

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.249

Low

645184

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

645201

GDE1
Glycerophosphocholine phosphodiesterase GDE1

1

0

Small-scale

0.249

Low

645207

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

645210

DBP9
ATP-dependent RNA helicase DBP9

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025