Protein: PSB5
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain subunit PRE2) (Multicatalytic endopeptidase complex subunit PRE2) (Proteasome component PRE2) (Proteinase YSCE subunit PRE2)

Gene: PSB5, PRE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P30656

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005777 - peroxisome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645137

PSB4
Proteasome subunit beta type-4

18

20

Small-scale

0.985

High

721263

PSA4
Proteasome subunit alpha type-4

9

20

Small-scale

0.967

High

721254

PSB1
Proteasome subunit beta type-1

8

20

Small-scale

0.966

High

675229

PSB3
Proteasome subunit beta type-3

8

20

Small-scale

0.965

High

636550

PSA7
Probable proteasome subunit alpha type-7

8

20

Small-scale

0.963

High

636637

PSA1
Proteasome subunit alpha type-1

7

20

Small-scale

0.962

High

661471

PSA2
Proteasome subunit alpha type-2

8

20

Small-scale

0.960

High

661382

PSA3
Proteasome subunit alpha type-3

7

20

Small-scale

0.958

High

662023

PSB6
Proteasome subunit beta type-6

7

20

Small-scale

0.958

High

721262

PSA6
Proteasome subunit alpha type-6

7

20

Small-scale

0.958

High

721236

PSB7
Proteasome subunit beta type-7

7

20

Small-scale

0.955

High

668369

PSB2
Proteasome subunit beta type-2

7

20

Small-scale

0.952

High

721237

PSA5
Proteasome subunit alpha type-5

6

20

Small-scale

0.935

High

721252

UMP1
Proteasome maturation factor UMP1

6

3

Small-scale

0.935

High

721265

BLM10
Proteasome activator BLM10

5

13

Small-scale

0.920

High

721287

RPN5
26S proteasome regulatory subunit RPN5

3

20

Small-scale

0.855

High

721235

PSB5
Proteasome subunit beta type-5

3

20

High-throughput

0.839

High

721271

PRS8
26S proteasome regulatory subunit 8 homolog

3

20

Small-scale

0.817

High

721245

PRS6A
26S proteasome regulatory subunit 6A

2

20

High-throughput

0.754

High

721266

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

9

20

Small-scale

0.743

High

679035

FUB1
Silencing boundary-establishment protein FUB1

2

3

High-throughput

0.694

High

721258

RPN10
26S proteasome regulatory subunit RPN10

3

15

High-throughput

0.662

High

721255

ECM29
Proteasome component ECM29

3

16

Small-scale

0.624

High

721246

PRS6B
26S proteasome regulatory subunit 6B homolog

1

20

High-throughput

0.618

High

721247

PRS7
26S proteasome regulatory subunit 7 homolog

1

20

High-throughput

0.618

High

721264

PRS4
26S proteasome regulatory subunit 4 homolog

1

20

High-throughput

0.618

High

721269

PRS10
26S proteasome subunit RPT4

1

20

High-throughput

0.618

High

670429

SIS1
Protein SIS1

2

6

High-throughput

0.601

High

721286

RPN8
26S proteasome regulatory subunit RPN8

2

20

Small-scale

0.584

High

721277

POC1
Proteasome chaperone 1

1

3

High-throughput

0.553

High

721253

HSM3
DNA mismatch repair protein HSM3

2

0

Small-scale

0.551

High

721273

STD1
Protein STD1

1

0

High-throughput

0.518

High

585875

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.515

High

660837

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

2

High-throughput

0.515

High

721248

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.514

High

517940

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.501

High

602356

PHO85
Cyclin-dependent protein kinase PHO85

1

7

High-throughput

0.501

High

721283

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.493

High

445321

CDC31
Cell division control protein 31

1

1

Small-scale

0.479

High

603021

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

706422

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

721238

RPN12
26S proteasome regulatory subunit RPN12

1

6

High-throughput

0.479

High

721239

RPN2
26S proteasome regulatory subunit RPN2

1

20

High-throughput

0.479

High

721241

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

721243

RAD23
UV excision repair protein RAD23

1

20

Small-scale

0.479

High

721244

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

721249

POC2
Proteasome assembly chaperone 2

1

3

High-throughput

0.479

High

721251

ATG8
Autophagy-related protein 8

1

7

High-throughput

0.479

High

721256

RPN1
26S proteasome regulatory subunit RPN1

1

20

High-throughput

0.479

High

721260

RPN3
26S proteasome regulatory subunit RPN3

1

11

High-throughput

0.479

High

721270

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

721276

RPN9
26S proteasome regulatory subunit RPN9

1

16

High-throughput

0.479

High

721280

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

721288

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

721268

POP6
Ribonucleases P/MRP protein subunit POP6

1

0

High-throughput

0.458

High

721275

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

392371

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

438526

UBC2
Ubiquitin-conjugating enzyme E2 2

1

6

Small-scale

0.445

High

523291

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

585688

UBC4
Ubiquitin-conjugating enzyme E2 4

1

4

Small-scale

0.445

High

585744

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

4

Small-scale

0.445

High

640547

UBC1
Ubiquitin-conjugating enzyme E2 1

1

5

Small-scale

0.445

High

721240

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

Small-scale

0.445

High

721242

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.445

High

721261

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

721250

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

721259

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

3

High-throughput

0.437

High

721282

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

721257

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.426

High

721274

RPN4
Protein RPN4

1

0

Small-scale

0.426

High

721285

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.426

High

721272

UBC7
Ubiquitin-conjugating enzyme E2 7

1

6

High-throughput

0.417

High

510274

HSP77
Import motor subunit, mitochondrial

1

9

High-throughput

0.407

High

721278

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

9

High-throughput

0.407

High

638891

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.249

Low

721279

RRG8
Required for respiratory growth protein 8, mitochondrial

1

0

High-throughput

0.249

Low

721281

GPI11
Glycosylphosphatidylinositol anchor biosynthesis protein 11

1

0

High-throughput

0.249

Low

574859

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low

625943

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.232

Low

721267

JAC1
J-type co-chaperone JAC1, mitochondrial

1

0

High-throughput

0.232

Low

721284

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025