HitPredict

Interactor 1: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20106982
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 316 Hs			1 346
+	Hs
		667651 CDN1C_HUMAN (1-316): 3.23e-37: 137: 100.00		CDK2_HUMAN (9-307): 4.88e-150: 426: 43.85
+	Hs
		892748 CDN1C_HUMAN (1-316): 3.23e-37: 137: 100.00		CDK3_HUMAN (9-306): 8.07e-143: 407: 45.00
+	Hs
		667600 CDN1A_HUMAN (17-148): 7.63e-31: 115: 29.20		CDK2_HUMAN (9-307): 4.88e-150: 426: 43.85
+	Hs
		807987 CDN1A_HUMAN (17-148): 7.63e-31: 115: 29.20		CDK7_HUMAN (1-346): 3.12e-147: 420: 100.00
+	Rn
		148252 O08769_RAT (9-201): 8.1e-25: 100: 24.35		CDK2_RAT (9-307): 2.64e-150: 426: 43.85
+	Hs
		667621 CDN1B_HUMAN (9-201): 9.8e-25: 100: 21.76		CDK2_HUMAN (9-307): 4.88e-150: 426: 43.85
+	Mm
		813541 CDN1A_MOUSE (16-155): 5.88e-33: 121: 27.78		CDK2_MOUSE (9-307): 2.01e-141: 405: 37.54
+	Hs
		443268 CDN1C_HUMAN (1-316): 3.23e-37: 137: 100.00		CDK1_HUMAN (9-298): 6.72e-135: 387: 43.00
+	Hs
		808021 CDN1A_HUMAN (17-148): 7.63e-31: 115: 29.20		CDK3_HUMAN (9-306): 8.07e-143: 407: 45.00
+	Hs
		857288 CDN1B_HUMAN (9-201): 9.8e-25: 100: 21.76		CDK7_HUMAN (1-346): 3.12e-147: 420: 100.00
+	Mm
		857019 CDN1B_MOUSE (9-201): 1.48e-28: 110: 23.83		CDK2_MOUSE (9-307): 2.01e-141: 405: 37.54
+	Hs
		857309 CDN1B_HUMAN (9-201): 9.8e-25: 100: 21.76		CDK3_HUMAN (9-306): 8.07e-143: 407: 45.00
+	Mm
		543014 CDN1A_MOUSE (16-155): 5.88e-33: 121: 27.78		CDK1_MOUSE (9-298): 2.7e-133: 383: 43.35
+	Hs
		443239 CDN1A_HUMAN (17-148): 7.63e-31: 115: 29.20		CDK1_HUMAN (9-298): 6.72e-135: 387: 43.00
+	Hs
		808023 CDN1A_HUMAN (17-148): 7.63e-31: 115: 29.20		CDK5_HUMAN (9-301): 1.74e-134: 386: 45.09
+	Xl
		658561 Q91646_XENLA (26-155): 1.9e-17: 81.3: 28.46		CDK2_XENLA (9-305): 2.8e-147: 418: 42.81
+	Rn
		1040986 SYNJ1_RAT (62-316): 8.89e-28: 115: 16.09		CDK5_RAT (9-301): 7.44e-134: 384: 45.09
+	Hs
		443254 CDN1B_HUMAN (9-201): 9.8e-25: 100: 21.76		CDK1_HUMAN (9-298): 6.72e-135: 387: 43.00
+	Hs
		857311 CDN1B_HUMAN (9-201): 9.8e-25: 100: 21.76		CDK5_HUMAN (9-301): 1.74e-134: 386: 45.09
+	Xl
		772464 Q91646_XENLA (26-155): 1.9e-17: 81.3: 28.46		CDK1A_XENLA (9-304): 9.64e-135: 387: 43.48