Protein: CDN1C
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)

Gene: CDN1C, CDKN1C
Organism: Homo sapiens
Interactions: 38
UniProt ID: P49918

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001501 - skeletal system development
GO:0001822 - kidney development
GO:0004860 - protein kinase inhibitor activity
GO:0004861 - cyclin-dependent protein serine/threonine kinase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667651

CDK2
Cyclin-dependent kinase 2

7

20

High-throughput

0.968

High

664683

CCND1
G1/S-specific cyclin-D1

6

20

Small-scale

0.948

High

629082

CCNA2
Cyclin-A2

5

15

Small-scale

0.927

High

718873

CCND3
G1/S-specific cyclin-D3

4

20

High-throughput

0.903

High

892749

CDK6
Cyclin-dependent kinase 6

4

20

Small-scale

0.895

High

549098

CDK4
Cyclin-dependent kinase 4

3

20

Small-scale

0.870

High

443268

CDK1
Cyclin-dependent kinase 1

3

20

High-throughput

0.861

High

718781

CCND2
G1/S-specific cyclin-D2

3

20

High-throughput

0.861

High

892748

CDK3
Cyclin-dependent kinase 3

3

20

High-throughput

0.861

High

573776

CCNB1
G2/mitotic-specific cyclin-B1

2

15

Small-scale

0.789

High

728118

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.724

High

325475

CCNB2
G2/mitotic-specific cyclin-B2

1

15

High-throughput

0.691

High

355340

CCNE2
G1/S-specific cyclin-E2

1

20

Small-scale

0.656

High

550921

PCNA
Proliferating cell nuclear antigen

2

5

Small-scale

0.631

High

892752

SKP2
S-phase kinase-associated protein 2

2

6

Small-scale

0.624

High

853626

MK08
Mitogen-activated protein kinase 8

1

18

Small-scale

0.618

High

892745

CDK7
Cyclin-dependent kinase 7

1

20

Small-scale

0.618

High

892746

CDK9
Cyclin-dependent kinase 9

1

20

Small-scale

0.618

High

519475

MYBB
Myb-related protein B

1

1

Small-scale

0.561

High

581632

MYOD1
Myoblast determination protein 1

1

2

Small-scale

0.561

High

892743

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

4

Small-scale

0.561

High

756128

MCM7
DNA replication licensing factor MCM7

1

5

Small-scale

0.552

High

822535

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.552

High

892747

LIMK1
LIM domain kinase 1

1

3

Small-scale

0.552

High

276677

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

4

High-throughput

0.536

High

442639

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.501

High

892757

FXL12
F-box/LRR-repeat protein 12

1

6

Small-scale

0.488

High

413421

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

704923

RBL1
Retinoblastoma-like protein 1

1

3

Small-scale

0.479

High

892744

ASCL1
Achaete-scute homolog 1

1

2

Small-scale

0.479

High

892750

E2F1
Transcription factor E2F1

1

4

Small-scale

0.479

High

892751

EP300
Histone acetyltransferase p300

1

8

Small-scale

0.479

High

892753

NDF1
Neurogenic differentiation factor 1

1

2

Small-scale

0.479

High

892754

FBX22
F-box only protein 22

1

1

Small-scale

0.479

High

892755

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.479

High

892756

NDF6
Neurogenic differentiation factor 6

1

2

Small-scale

0.479

High

667214

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025