HitPredict

Interactor 1: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Interactor 2: CILK1 (Q9UPZ9)
Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK)
Gene: CILK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 79 Hs			1 632
+	Hs
		625283 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		895413 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		625164 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		706796 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		414843 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	Hs
		414778 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	At
		188136 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKA1_ARATH (1-287): 2.35e-134: 396: 39.86
+	Dm
		618415 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK1_DROME (1-286): 3.57e-133: 393: 37.59
+	At
		621728 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CDKA1_ARATH (1-287): 2.35e-134: 396: 39.86
+	Hs
		895414 CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	Hs
		706797 CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	Dm
		618387 CKS1_DROME (4-72): 4.45e-35: 115: 78.26		CDK1_DROME (1-286): 3.57e-133: 393: 37.59
+	At
		188163 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CDKD2_ARATH (1-333): 3.83e-123: 370: 36.42
+	At
		1321252 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CDKD2_ARATH (1-333): 3.83e-123: 370: 36.42
+	At
		1321299 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CDKD1_ARATH (2-324): 5.64e-122: 368: 34.05
+	Ce
		712291 CKS1_CAEEL (4-78): 6.93e-42: 133: 65.33		CDK1_CAEEL (1-284): 7.7e-57: 196: 37.25
+	At
		188156 CKS1_ARATH (5-73): 1.35e-37: 122: 69.57		CKB21_ARATH (1-284): 6.78e-58: 199: 39.00
+	At
		1227962 CKS2_ARATH (5-78): 3.45e-37: 120: 67.57		CKB21_ARATH (1-284): 6.78e-58: 199: 39.00
+	Dm
		618471 Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83		CDK2_DROME (1-285): 2.83e-56: 194: 38.33
+	Dm
		618437 CKS1_DROME (4-72): 4.45e-35: 115: 78.26		CDK2_DROME (1-285): 2.83e-56: 194: 38.33