Protein: SPB12
Serpin B12

Gene: SPB12, SERPINB12
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q96P63

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1332797

FNDC5
Fibronectin type III domain-containing protein 5

1

7

High-throughput

0.691

High

671842

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.618

High

762249

TRY3
Trypsin-3

1

20

High-throughput

0.618

High

820722

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

1255126

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1399463

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

564237

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

1055958

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

1060122

BAX
Apoptosis regulator BAX

1

2

High-throughput

0.536

High

1115925

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

1134337

IMB1
Importin subunit beta-1

1

1

High-throughput

0.536

High

1275331

APTX
Aprataxin

1

3

High-throughput

0.536

High

1137956

TNIP1
TNFAIP3-interacting protein 1

2

3

High-throughput

0.533

High

1117208

THOC5
THO complex subunit 5

1

0

High-throughput

0.513

High

1146332

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.513

High

1399470

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1399473

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

983691

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

4

High-throughput

0.489

High

1112961

CUL2
Cullin-2

1

6

High-throughput

0.489

High

1290378

MOGT3
2-acylglycerol O-acyltransferase 3

1

6

High-throughput

0.489

High

1399458

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.489

High

141623

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

294202

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

349209

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.479

High

363731

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

401321

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

414436

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

456828

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

537737

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

587774

DESP
Desmoplakin

1

3

High-throughput

0.479

High

589451

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

607012

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

729605

CASPE
Caspase-14

1

8

High-throughput

0.479

High

872646

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

888261

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

986647

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

990621

1433Z
14-3-3 protein zeta/delta

1

3

Small-scale

0.479

High

1024773

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1036786

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

1092210

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

1107116

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1115008

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

1117982

PKP1
Plakophilin-1

1

6

High-throughput

0.479

High

1118130

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.479

High

1118242

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

1125193

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

1140714

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1204023

FILA2
Filaggrin-2

1

9

High-throughput

0.479

High

1250899

SOSD1
Sclerostin domain-containing protein 1

1

1

Small-scale

0.479

High

1289828

PAQR2
Adiponectin receptor protein 2

1

1

Small-scale

0.479

High

1294328

TRI50
E3 ubiquitin-protein ligase TRIM50

1

6

Small-scale

0.479

High

1295705

HORN
Hornerin

1

8

High-throughput

0.479

High

1364211

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1380093

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

1386675

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.479

High

1399453

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.479

High

1399459

S10AE
Protein S100-A14

1

9

High-throughput

0.479

High

1399460

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1399461

ANLN
Anillin

1

2

High-throughput

0.479

High

1399464

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.479

High

1399466

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1399467

UBQL2
Ubiquilin-2

1

7

High-throughput

0.479

High

1399471

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

1399472

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

4

Small-scale

0.479

High

1155679

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.470

High

370350

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

423694

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

577862

PLAK
Junction plakoglobin

1

0

High-throughput

0.458

High

1030487

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1062285

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.458

High

1064470

DSC1
Desmocollin-1

1

0

High-throughput

0.458

High

1132904

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1213461

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1213813

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1218635

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1293801

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

1399450

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1399452

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1399456

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1399457

AKTIP
AKT-interacting protein

1

0

Small-scale

0.458

High

1399465

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

1399474

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

911655

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

1209530

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1311018

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.445

High

1326038

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

180903

TIF1A
Transcription intermediary factor 1-alpha

1

12

Small-scale

0.437

High

302615

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

High-throughput

0.437

High

372883

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

406526

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.437

High

696256

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

765809

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.437

High

768929

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

970940

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1194297

LARP7
La-related protein 7

1

1

High-throughput

0.437

High

1288562

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1314370

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

1346893

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.437

High

1389540

RN125
E3 ubiquitin-protein ligase RNF125

1

7

Small-scale

0.437

High

1399451

FACD2
Fanconi anemia group D2 protein

1

12

High-throughput

0.437

High

1399454

PRD14
PR domain zinc finger protein 14

1

5

Small-scale

0.437

High

1399455

RNF38
E3 ubiquitin-protein ligase RNF38

1

8

Small-scale

0.437

High

1399462

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

1399468

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.437

High

610038

VGFR1
Vascular endothelial growth factor receptor 1

1

0

Small-scale

0.426

High

1063842

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.426

High

1066751

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

1119259

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

87523

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

1227292

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

158700

UTY
Histone demethylase UTY

1

0

High-throughput

0.279

Low

479464

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.279

Low

1392764

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

209643

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.249

Low

1010699

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1213877

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

1214855

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.249

Low

1383392

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.249

Low

1399469

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.249

Low

1094473

IFT88
Intraflagellar transport protein 88 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025