HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: ZNRF3 (Q9ULT6)
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
Gene: ZNRF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 936
+	Hs
		1148281 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RNF43_HUMAN (42-780): 1.31e-112: 366: 28.76
+	Hs
		849341 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF43_HUMAN (42-780): 1.31e-112: 366: 28.76
+	Hs
		610305 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		610333 UB2D2_HUMAN (4-149): 9.96e-80: 233: 46.58		CBL_HUMAN (293-792): 9.2e-80: 280: 13.33
+	Hs
		849382 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN128_HUMAN (38-437): 1.17e-80: 269: 19.32
+	Hs
		1356934 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RN150_HUMAN (27-420): 3.75e-79: 266: 18.88
+	Hs
		849485 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN150_HUMAN (27-420): 3.75e-79: 266: 18.88
+	Hs
		1204871 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		GOLI_HUMAN (45-423): 7.46e-73: 248: 19.90
+	Hs
		849359 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		GOLI_HUMAN (45-423): 7.46e-73: 248: 19.90
+	Hs
		1332598 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RN167_HUMAN (32-390): 7.8e-71: 240: 20.27
+	Hs
		849446 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RN167_HUMAN (32-390): 7.8e-71: 240: 20.27
+	Hs
		207572 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		RNF13_HUMAN (59-425): 1.75e-69: 237: 18.83
+	Hs
		207545 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		RNF13_HUMAN (59-425): 1.75e-69: 237: 18.83
+	Hs
		207553 UB2D2_HUMAN (4-149): 9.96e-80: 233: 46.58		RNF13_HUMAN (59-425): 1.75e-69: 237: 18.83
+	Hs
		1262545 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		ZNRF4_HUMAN (57-415): 1.66e-54: 197: 17.26
+	Hs
		849385 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		ZNRF4_HUMAN (57-415): 1.66e-54: 197: 17.26
+	Hs
		1356614 UB2D4_HUMAN (4-149): 5.39e-81: 236: 45.89		AMFR_HUMAN (197-568): 3.99e-47: 181: 14.60
+	Hs
		849484 UB2D1_HUMAN (4-149): 3.22e-80: 235: 45.21		AMFR_HUMAN (197-568): 3.99e-47: 181: 14.60
+	At
		715117 UBC8_ARATH (4-149): 2.42e-80: 235: 46.58		ATL78_ARATH (190-367): 1.83e-24: 104: 21.93
+	At
		715148 UBC10_ARATH (4-149): 8e-80: 234: 45.89		ATL78_ARATH (190-367): 1.83e-24: 104: 21.93