HitPredict

Interactor 1: RAP2B (P61225)
Ras-related protein Rap-2b (EC 3.6.5.2)
Gene: RAP2B

Interactor 2: RPGF1 (Q13905)
Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
Gene: RAPGEF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9266971
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0032486 - Rap protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1077
+	Hs
		919625 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF1_HUMAN (1-1077): 0: 1636: 100.00
+	Hs
		486052 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RGL1_HUMAN (670-1077): 2.69e-103: 344: 21.82
+	Hs
		486045 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF5_HUMAN (712-1064): 1.95e-87: 295: 24.11
+	Hs
		486043 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF4_HUMAN (819-1066): 2.11e-82: 291: 28.24
+	Hs
		919681 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RGL1_HUMAN (670-1077): 2.69e-103: 344: 21.82
+	Dm
		442959 RAP1_DROME (1-165): 7.45e-82: 241: 65.46		Q86BI2_DROME (653-1071): 7.98e-93: 315: 20.19
+	Dm
		442968 RAP1_DROME (1-165): 7.45e-82: 241: 65.46		Q9GR11_DROME (653-1071): 1.07e-92: 315: 20.19
+	Hs
		486024 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		GNDS_HUMAN (821-1077): 1.08e-72: 261: 26.69
+	Dm
		442969 RAP1_DROME (1-165): 7.45e-82: 241: 65.46		Q9U4U5_DROME (653-1071): 2.78e-90: 312: 20.19
+	Hs
		919657 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF5_HUMAN (712-1064): 1.95e-87: 295: 24.11
+	Hs
		919656 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF4_HUMAN (819-1066): 2.11e-82: 291: 28.24
+	Hs
		897981 RAP2B_HUMAN (1-183): 8.63e-88: 256: 100.00		GNDS_HUMAN (821-1077): 1.08e-72: 261: 26.69
+	Hs
		919618 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		GNDS_HUMAN (821-1077): 1.08e-72: 261: 26.69
+	Hs
		313164 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF3_HUMAN (841-1011): 9.82e-22: 103: 33.52
+	Hs
		486041 RAP2A_HUMAN (1-182): 8.69e-103: 295: 91.21		RPGF6_HUMAN (843-1011): 2.79e-18: 93.2: 35.03
+	Hs
		897996 RAP2B_HUMAN (1-183): 8.63e-88: 256: 100.00		RPGF2_HUMAN (843-1011): 7.66e-20: 98.2: 36.72
+	Dm
		442976 RAP1_DROME (1-165): 7.45e-82: 241: 65.46		Q9VMF3_DROME (815-1011): 1.58e-19: 97.1: 33.65
+	Hs
		313171 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF3_HUMAN (841-1011): 9.82e-22: 103: 33.52
+	Hs
		919687 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF2_HUMAN (843-1011): 7.66e-20: 98.2: 36.72
+	Hs
		919653 RAP1A_HUMAN (1-183): 3.49e-78: 232: 60.87		RPGF6_HUMAN (843-1011): 2.79e-18: 93.2: 35.03