HitPredict

Interactor 1: CCNE1 (P50756)
G1/S-specific cyclin-E1
Gene: cyce1

Interactor 2: Q5V9L9 (Q5V9L9)
Cyclin dependent kinase inhibitor p16Xic2 (Cyclin-dependent kinase inhibitor 1)
Gene: cdkn1a.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23607668
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Xl			1 138
+	Xl
		898054 CCNE1_XENLA (1-408): 1.32e-140: 408: 100.00		Q91646_XENLA (7-111): 4.58e-39: 132: 23.81
+	Xl
		205908 CCNE3_XENLA (1-408): 1.86e-139: 405: 91.42		Q91646_XENLA (7-111): 4.58e-39: 132: 23.81
+	Hs
		666957 CCNE1_HUMAN (5-407): 2.89e-132: 387: 59.85		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		666961 CCNE1_HUMAN (5-407): 2.89e-132: 387: 59.85		CDN1B_HUMAN (9-117): 5.05e-39: 131: 32.43
+	Mm
		857022 CCNE1_MOUSE (1-407): 3.26e-127: 374: 57.74		CDN1B_MOUSE (9-117): 4.75e-40: 134: 32.43
+	Hs
		91541 C9J2U0_HUMAN (13-407): 1.62e-113: 337: 54.52		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Mm
		666784 CCNB1_MOUSE (1-376): 2.12e-103: 314: 18.80		CDN1A_MOUSE (14-129): 6.56e-42: 137: 35.00
+	Hs
		325472 CCNB2_HUMAN (17-376): 2.4e-103: 313: 18.53		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		325473 CCNB2_HUMAN (17-376): 2.4e-103: 313: 18.53		CDN1B_HUMAN (9-117): 5.05e-39: 131: 32.43
+	Mm
		857016 CCNA2_MOUSE (7-374): 1.74e-101: 309: 22.11		CDN1B_MOUSE (9-117): 4.75e-40: 134: 32.43
+	Hs
		355337 CCNE2_HUMAN (7-402): 1.08e-101: 309: 44.64		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		355339 CCNE2_HUMAN (7-402): 1.08e-101: 309: 44.64		CDN1B_HUMAN (9-117): 5.05e-39: 131: 32.43
+	Hs
		808019 CCNA1_HUMAN (22-375): 4.28e-101: 309: 19.56		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		857308 CCNA1_HUMAN (22-375): 4.28e-101: 309: 19.56		CDN1B_HUMAN (9-117): 5.05e-39: 131: 32.43
+	Hs
		573769 CCNB1_HUMAN (56-376): 1.36e-100: 307: 21.04		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		629075 CCNA2_HUMAN (2-374): 1.12e-100: 307: 21.45		CDN1A_HUMAN (15-129): 3.68e-39: 131: 34.27
+	Hs
		629078 CCNA2_HUMAN (2-374): 1.12e-100: 307: 21.45		CDN1B_HUMAN (9-117): 5.05e-39: 131: 32.43
+	Hs
		325475 CCNB2_HUMAN (17-376): 2.4e-103: 313: 18.53		CDN1C_HUMAN (1-105): 4.05e-29: 109: 21.24
+	Hs
		355340 CCNE2_HUMAN (7-402): 1.08e-101: 309: 44.64		CDN1C_HUMAN (1-105): 4.05e-29: 109: 21.24
+	Hs
		629082 CCNA2_HUMAN (2-374): 1.12e-100: 307: 21.45		CDN1C_HUMAN (1-105): 4.05e-29: 109: 21.24