HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: RP3A (Q9Y2J0)
Rabphilin-3A (Exophilin-1)
Gene: RPH3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0030141 - secretory granule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 694
+	Mm
		770469 RAB3D_MOUSE (2-221): 6.71e-86: 255: 40.46		RP3A_MOUSE (1-694): 0: 570: 85.08
+	Mm
		866421 RB27A_MOUSE (1-221): 1.07e-84: 252: 95.93		RP3A_MOUSE (1-694): 0: 570: 85.08
+	Mm
		866419 RB27B_MOUSE (1-221): 8.93e-81: 242: 70.59		RP3A_MOUSE (1-694): 0: 570: 85.08
+	Rn
		866423 RAB3A_RAT (2-219): 3.97e-86: 255: 41.28		RP3A_RAT (1-694): 0: 556: 84.29
+	Hs
		902287 RB27A_HUMAN (1-221): 4.79e-85: 253: 100.00		SYTL4_HUMAN (42-686): 1.31e-122: 382: 22.46
+	Dm
		304433 O76901_DROME (11-186): 5.32e-81: 243: 62.50		Q9W2R9_DROME (7-689): 1.89e-126: 390: 30.27
+	Hs
		902284 RB27A_HUMAN (1-221): 4.79e-85: 253: 100.00		SYTL5_HUMAN (47-685): 6.42e-121: 379: 20.54
+	Mm
		1424410 RB27A_MOUSE (1-221): 1.07e-84: 252: 95.93		SYTL4_MOUSE (42-686): 3.43e-121: 378: 21.49
+	Mm
		1281848 RB27A_MOUSE (1-221): 1.07e-84: 252: 95.93		SYTL5_MOUSE (47-687): 5.33e-115: 364: 19.97
+	Hs
		902306 RB27A_HUMAN (1-221): 4.79e-85: 253: 100.00		RPH3L_HUMAN (1-292): 4.19e-114: 347: 39.15
+	Rn
		236533 RAB3A_RAT (2-219): 3.97e-86: 255: 41.28		RPH3L_RAT (1-298): 7.86e-99: 307: 38.02
+	Hs
		639111 RB27A_HUMAN (1-221): 4.79e-85: 253: 100.00		SYT1_HUMAN (268-693): 3.18e-84: 273: 25.34
+	Hs
		1214374 RAB1B_HUMAN (3-219): 2.46e-82: 245: 35.02		SYT6_HUMAN (261-687): 1.47e-83: 274: 26.48
+	Hs
		136168 RAB1A_HUMAN (1-220): 1.62e-83: 248: 34.69		SYT5_HUMAN (341-692): 1.03e-74: 247: 29.01
+	Ce
		110098 G5EBS5_CAEEL (4-213): 9.09e-88: 259: 59.05		RBF1_CAEEL (1-408): 4.2e-60: 220: 26.34
+	Mm
		770473 RAB3D_MOUSE (2-221): 6.71e-86: 255: 40.46		RPH3L_MOUSE (1-185): 3.41e-53: 187: 50.00
+	Mm
		1260488 RB27A_MOUSE (1-221): 1.07e-84: 252: 95.93		RPH3L_MOUSE (1-185): 3.41e-53: 187: 50.00
+	Mm
		1408903 RB27A_MOUSE (1-221): 1.07e-84: 252: 95.93		SYTL3_MOUSE (559-694): 3.04e-20: 97.4: 23.36
+	Hs
		902271 RB27A_HUMAN (1-221): 4.79e-85: 253: 100.00		SYTL3_HUMAN (501-694): 6.47e-20: 96.2: 18.63
+	Mm
		770482 RAB3D_MOUSE (2-221): 6.71e-86: 255: 40.46		RIMS1_MOUSE (234-546): 8.78e-16: 83.9: 15.29