HitPredict

Interactor 1: RB27A (Q9ERI2)
Ras-related protein Rab-27A (EC 3.6.5.2)
Gene: Rab27a

Interactor 2: SYTL4 (Q9R0Q1)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	18940603, 11773082
Identification Methods	pull down, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0030141 - secretory granule GO:0071985 - multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Mm			1 673
+	Hs
		902287 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYTL4_HUMAN (1-673): 0: 557: 90.34
+	Hs
		126003 RB27B_HUMAN (1-221): 1.33e-81: 244: 71.95		SYTL4_HUMAN (1-673): 0: 557: 90.34
+	Hs
		902284 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYTL5_HUMAN (2-671): 3.22e-155: 467: 39.51
+	Hs
		126000 RB27B_HUMAN (1-221): 1.33e-81: 244: 71.95		SYTL5_HUMAN (2-671): 3.22e-155: 467: 39.51
+	Mm
		1281848 RB27A_MOUSE (1-221): 1.78e-85: 254: 100.00		SYTL5_MOUSE (2-671): 2.68e-149: 453: 36.42
+	Mm
		1408903 RB27A_MOUSE (1-221): 1.78e-85: 254: 100.00		SYTL3_MOUSE (1-663): 1.54e-122: 379: 30.09
+	Hs
		902271 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYTL3_HUMAN (1-663): 8.83e-122: 377: 29.15
+	Hs
		125994 RB27B_HUMAN (1-221): 1.33e-81: 244: 71.95		SYTL3_HUMAN (1-663): 8.83e-122: 377: 29.15
+	Hs
		136168 RAB1A_HUMAN (1-219): 1.21e-84: 251: 34.84		SYT5_HUMAN (354-650): 3.51e-100: 313: 30.20
+	Mm
		1408905 RB27A_MOUSE (1-221): 1.78e-85: 254: 100.00		SYTL2_MOUSE (148-669): 2.42e-87: 295: 33.77
+	Hs
		902280 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYTL1_HUMAN (4-486): 1.32e-40: 158: 13.50
+	Hs
		125997 RB27B_HUMAN (1-221): 1.33e-81: 244: 71.95		SYTL1_HUMAN (4-486): 1.32e-40: 158: 13.50
+	Mm
		1408921 RB27A_MOUSE (1-221): 1.78e-85: 254: 100.00		SYTL1_MOUSE (4-486): 3.54e-32: 133: 14.72
+	Hs
		639111 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYT1_HUMAN (471-673): 7.63e-31: 127: 19.21
+	Mm
		770469 RAB3D_MOUSE (2-221): 7.11e-86: 255: 40.46		RP3A_MOUSE (521-673): 1.88e-28: 123: 22.02
+	Mm
		866421 RB27A_MOUSE (1-221): 1.78e-85: 254: 100.00		RP3A_MOUSE (521-673): 1.88e-28: 123: 22.02
+	Hs
		902298 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		SYTL2_HUMAN (4-358): 4.35e-28: 122: 14.05
+	Hs
		902307 RB27A_HUMAN (1-221): 9.68e-86: 254: 95.93		RP3A_HUMAN (521-673): 4.35e-28: 121: 22.62
+	Hs
		1214374 RAB1B_HUMAN (3-219): 1.12e-83: 249: 34.56		SYT6_HUMAN (121-488): 4.19e-28: 120: 15.49
+	Mm
		770482 RAB3D_MOUSE (2-221): 7.11e-86: 255: 40.46		RIMS1_MOUSE (113-639): 1.66e-16: 86.1: 13.75