HitPredict

Interactor 1: SMCA4 (P51532)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Gene: SMARCA4

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 35271311, 14530259, 16217013, 28977666, 32744500, 40437099, 11003653
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Bromodomain~PHD, Helicase_C~Helicase_C, Helicase_C~SNF2-rel_dom, HSA~SNF2-rel_dom, Helicase_C~SnAC, SNF2-rel_dom~SnAC, Chromo~SNF2-rel_dom, SNF2-rel_dom~SNF2-rel_dom
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001221 - transcription coregulator binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
and 12 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 11Aug2025